ArticleHypertension (Dallas, Tex. : 1979)2015
Role of Chemoreceptor Activation in Hemodynamic Responses to Electrical Stimulation of the Carotid Sinus in Conscious Rats.
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Immunohistochemical Detection of PIEZO Ion Channels in the Human Carotid Sinus and Carotid Body.Biomolecules · 2025Article
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Perioperative blood pressure and heart rate alterations after carotid body tumor excision: a retrospective study of 108 cases.BMC anesthesiology · 2022Observational
- Low intensity stimulation of aortic baroreceptor afferent fibers as a potential therapeutic alternative for hypertension treatment.Scientific reports · 2022Article
- The carotid body: A novel key player in neuroimmune interactions.Frontiers in immunology · 2022Review
- The ability of baroreflex activation to improve blood pressure and resistance vessel function in spontaneously hypertensive rats is dependent on stimulation parameters.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation.Frontiers in neuroscience · 2021Article
- Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis.Scientific reports · 2020Article
- Electrical stimulation of the carotid sinus lowers arterial pressure and improves heart rate variability in L-NAME hypertensive conscious rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation.Journal of neuroinflammation · 2019Article
- Distribution and morphology of baroreceptors in the rat carotid sinus as revealed by immunohistochemistry for P2X3 purinoceptors.Histochemistry and cell biology · 2019Article
- [Baroreceptor activation therapy for therapy-resistant hypertension: indications and patient selection : Recommendations of the BAT consensus group 2017].Der Internist · 2017Article
- Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation.Scientific reports · 2017Article
- Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel.Journal of the American Heart Association · 2017Article
- Chronic Interactions Between Carotid Baroreceptors and Chemoreceptors in Obesity Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
Electric carotid baroreflex activation has been used to treat patients with resistant hypertension. It is hypothesized that, in conscious rats, combined activation of carotid baro- and chemoreceptors afferences attenuates the reflex hypotension. Rats were divided into 4 groups: (1) control group, with unilateral denervation of the right carotid chemoreceptors; (2) chemoreceptor denervation group, with bilateral ligation of the carotid body artery; (3) baroreceptor denervation group, with unilateral denervation of the left carotid baroreceptors and right carotid chemoreceptors; and (4) carotid bifurcation denervation group, with denervation of the left carotid baroreceptors and chemoreceptors, plus denervation of the right carotid chemoreceptors. Animals were subjected to 4 rounds of electric stimulation (5 V, 1 ms), with 15, 30, 60, and 90 Hz applied randomly for 20 s. Electric stimulation caused greater hypotensive responses in the chemoreceptor denervation group than in the control group, at 60 Hz (-37 versus -19 mm Hg) and 90 Hz (-33 versus -19 mm Hg). The baroreceptor denervation group showed hypertensive responses at all frequencies of stimulation. In contrast, the carotid sinus denervation group showed no hemodynamic responses. The control group presented no changes in heart rate, whereas the chemoreceptor denervation group and the baroreceptor denervation group showed bradycardic responses. These data demonstrate that carotid chemoreceptor activation attenuates the reflex hypotension caused by combined electric stimulation of the carotid sinus and the carotid sinus nerve in conscious rats. These findings may provide useful insight for clinical studies using baroreflex activation therapy in resistant hypertension and heart failure.
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