ArticleNature communications2015
Transient signal generation in a self-assembled nanosystem fueled by ATP.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Kinetically programmed pathway-dependent autonomous reversibility in biomimetic self-assembly of nanoparticles.Chemical science · 2026Article
- Article
- Review
- Chirality Makes or Breaks Chemically Driven Self-Assembly.Angewandte Chemie (International ed. in English) · 2025Article
- ATP-Regulated Formation of Transient Peptide Amphiphiles Superstructures.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- CryoEM reveals the complex self-assembly of a chemically driven disulfide hydrogel.Chemical science · 2024Article
- Timed Pulses in DNA Strand Displacement Reactions.Journal of the American Chemical Society · 2023Article
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- Transient Host-Guest Complexation To Control Catalytic Activity.Journal of the American Chemical Society · 2022Article
- Self-Regulating Colloidal Co-Assemblies That Accelerate Their Own Destruction via Chemo-Structural Feedback.Angewandte Chemie (International ed. in English) · 2022Article
- Progressive Local Accumulation of Self-Assembled Nanoreactors in a Hydrogel Matrix through Repetitive Injections of ATP.Journal of the American Chemical Society · 2022Article
- Chemically Fueled Self-Assembly in Biology and Chemistry.Angewandte Chemie (International ed. in English) · 2021Review
- Autonomous Transient pH Flips Shaped by Layered Compartmentalization of Antagonistic Enzymatic Reactions.Angewandte Chemie (International ed. in English) · 2021Article
- On the use of catalysis to bias reaction pathways in out-of-equilibrium systems.Chemical science · 2021Article
- Enhanced catalytic activity under non-equilibrium conditions.Nature nanotechnology · 2020Article
- ATP-powered molecular recognition to engineer transient multivalency and self-sorting 4D hierarchical systems.Nature communications · 2020Article
- Multiple Light Control Mechanisms in ATP-Fueled Non-equilibrium DNA Systems.Angewandte Chemie (International ed. in English) · 2020Article
- Pathway Complexity in Fuel-Driven DNA Nanostructures with Autonomous Reconfiguration of Multiple Dynamic Steady States.Journal of the American Chemical Society · 2020Article
- Dissipative Catalysis with a Molecular Machine.Angewandte Chemie (International ed. in English) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fundamental difference exists in the way signal generation is dealt with in natural and synthetic systems. While nature uses the transient activation of signalling pathways to regulate all cellular functions, chemists rely on sensory devices that convert the presence of an analyte into a steady output signal. The development of chemical systems that bear a closer analogy to living ones (that is, require energy for functioning, are transient in nature and operate out-of-equilibrium) requires a paradigm shift in the design of such systems. Here we report a straightforward strategy that enables transient signal generation in a self-assembled system and show that it can be used to mimic key features of natural signalling pathways, which are control over the output signal intensity and decay rate, the concentration-dependent activation of different signalling pathways and the transient downregulation of catalytic activity. Overall, the reported methodology provides temporal control over supramolecular processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.