ReviewExpert opinion on biological therapy2015
Challenges in engineering osteochondral tissue grafts with hierarchical structures.
Review in Expert opinion on biological therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Visualized trends and bibliometric analysis in ankle cartilage repair from 2004 to 2024.Frontiers in medicine · 2024Pooled it
- Visualized Trends and Bibliometric Analysis in 3D Printing for Osteochondral Repair: A Comprehensive Research Study from 2010 to 2024.3D printing and additive manufacturing · 2026Article
- Nanofibrous scaffolds for bone and cartilage regeneration.Applied physics reviews · 2025Article
- In Vitro Investigation of 3D Printed Hydrogel Scaffolds with Electrospun Tidemark Component for Modeling Osteochondral Interface.Gels (Basel, Switzerland) · 2024Article
- A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration.Biomaterials and biosystems · 2024Article
- Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies.Bioactive materials · 2023Review
- A Novel Approach for Design and Manufacturing of Curvature-Featuring Scaffolds for Osteochondral Repair.Polymers · 2023Article
- Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices.Journal of functional biomaterials · 2023Article
- Progress in 3D Bioprinting Technology for Osteochondral Regeneration.Pharmaceutics · 2022Review
- Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing.Pharmaceutics · 2021Review
- Beyond Cartilage Repair: The Role of the Osteochondral Unit in Joint Health and Disease.Tissue engineering. Part B, Reviews · 2019Review
- Biphasic Scaffolds from Marine Collagens for Regeneration of Osteochondral Defects.Marine drugs · 2018Article
- A modular approach to creating large engineered cartilage surfaces.Journal of biomechanics · 2018Article
- Recent advances on gradient hydrogels in biomimetic cartilage tissue engineering.F1000Research · 2017Review
- Bioprinting of osteochondral tissues: A perspective on current gaps and future trends.International journal of bioprinting · 2017Article
- Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders.Current osteoporosis reports · 2016Review
- Nanoparticulate Mineralized Collagen Scaffolds and BMP-9 Induce a Long-Term Bone Cartilage Construct in Human Mesenchymal Stem Cells.Advanced healthcare materials · 2016Article
- Biomimetic gradient scaffold of collagen-hydroxyapatite for osteochondral regeneration.Journal of tissue engineeringArticle
- Biofabrication of the osteochondral unit and its applications: Current and future directions for 3D bioprinting.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionA major hurdle in treating osteochondral (OC) defects is the different healing abilities of two types of tissues involved - articular cartilage and subchondral bone. Biomimetic approaches to OC-construct engineering, based on recapitulation of biological principles of tissue development and regeneration, have potential for providing new treatments and advancing fundamental studies of OC tissue repair. AREAS COVERED: This review on state of the art in hierarchical OC tissue graft engineering is focused on tissue engineering approaches designed to recapitulate the native milieu of cartilage and bone development. These biomimetic systems are discussed with relevance to bioreactor cultivation of clinically sized, anatomically shaped human cartilage/bone constructs with physiologic stratification and mechanical properties. The utility of engineered OC tissue constructs is evaluated for their use as grafts in regenerative medicine, and as high-fidelity models in biological research. EXPERT OPINION: A major challenge in engineering OC tissues is to generate a functionally integrated stratified cartilage-bone structure starting from one single population of mesenchymal cells, while incorporating perfusable vasculature into the bone, and in bone-cartilage interface. To this end, new generations of advanced scaffolds and bioreactors, implementation of mechanical loading regimens and harnessing of inflammatory responses of the host will likely drive the further progress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.