ArticleComputer methods in biomechanics and biomedical engineering2016
A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics.
Article in Computer methods in biomechanics and biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 34 citations in OpenAlex.
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- Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates.Journal of neural engineering · 2025Article
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- Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering.Bioengineering (Basel, Switzerland) · 2024Article
- Investigation of crystalline lens overshooting:Frontiers in bioengineering and biotechnology · 2024Article
- Complexity of crystalline lens wobbling investigated by means of combined mechanical and optical simulations.Biomedical optics express · 2023Article
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- Ocular pulse amplitude (OPA) in canineFrontiers in bioengineering and biotechnology · 2023Article
- Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics.Fluids and barriers of the CNS · 2022Article
- Ocular biomechanics during improvised explosive device blast: A computational study using eye-specific models.Injury · 2022Article
- Ocular biomechanics due to ground blast reinforcement.Computer methods and programs in biomedicine · 2021Article
- Assessment of the viscoelastic mechanical properties of the porcine optic nerve head using micromechanical testing and finite element modeling.Acta biomaterialia · 2021Article
- Biomechanics of the optic nerve head and sclera in canine glaucoma: A brief review.Veterinary ophthalmology · 2021Review
- Validation of Hydraulic Mechanism during Blowout Trauma of Human Orbit Depending on the Method of Load Application.Applied bionics and biomechanics · 2021Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Article
- A generalised porous medium approach to study thermo-fluid dynamics in human eyes.Medical & biological engineering & computing · 2018Article
- Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.Investigative ophthalmology & visual science · 2018Article
- Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.Investigative ophthalmology & visual science · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand the effect variations in ocular material properties can have on ONH biomechanics. An axisymmetric model of the human eye was constructed to parametrically study how changes in the permeabilities of retina-Bruch's-choroid complex (k(RBC)), sclera k(sclera), uveoscleral pathway (k(UVSC)) and trabecular meshwork k(TM) as well as how changes in the stiffness of the lamina cribrosa (LC) and sclera affect IOP, LC strains, and translaminar interstitial pressure gradients (TLIPG). Decreasing k(RBC) from 5 × 10(- 12) to 5 × 10(- 13) m/s increased IOP and LC strains by 17%, and TLIPG by 21%. LC strains increased by 13% and 9% when the scleral and LC moduli were decreased by 48% and 50%, respectively. In addition to the trabecular meshwork and uveoscleral pathway, the retina-Bruch's-choroid complex had an important effect on IOP, LC strains, and TLIPG. Changes in k(RBC) and scleral modulus resulted in nonlinear changes in the IOP, and LC strains especially at the lowest k(TM) and k(UVSC). This study demonstrates that porohyperelastic modeling provides a novel method for computationally studying the biomechanical environment of the ONH. Porohyperelastic simulations of ocular tissues may help provide further insight into the complex biomechanical environment of posterior ocular tissues in POAG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.