ReviewClinical reviews in allergy & immunology2016
Eosinophilic Esophagitis: A Comprehensive Review.
Review in Clinical reviews in allergy & immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Eosinophilic Esophagitis following Oral Immunotherapy: A Systematic Review and Meta-Analysis.International archives of allergy and immunology · 2026Pooled it
- Dysregulated IL-2 signaling and T-cell subset shifts are associated with eosinophilic esophagitis activity.Biochemistry and biophysics reports · 2026Article
- A New Differential Gene Expression Based Simulated Annealing for Solving Gene Selection Problem: A Case Study on Eosinophilic Esophagitis and Few Other Gastro-intestinal Diseases.Biochemical genetics · 2025Article
- Eosinophilic gastrointestinal disorders: variations in eosinophilic counts among investigators and staining methods.Fujita medical journal · 2025Article
- Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications.Journal of clinical medicine · 2023Review
- Allergy-Test-Based Elimination Diets for the Treatment of Eosinophilic Esophagitis: A Systematic Review of Their Efficacy.Journal of clinical medicine · 2022Review
- Pathogenesis, diagnosis, dietary management, and prevention of gastrointestinal disorders in the paediatric population.Italian journal of pediatrics · 2022Review
- Food allergy in children-the current status and the way forward.World journal of clinical pediatrics · 2022Review
- Sensitizations to wheat and strawberry: are they a tangible threat to atopic Egyptian.American journal of clinical and experimental immunology · 2022Article
- Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes.Digestive diseases and sciences · 2021Article
- Association of Eosinophilic Esophagitis and Human Immunodeficiency Virus.Digestive diseases and sciences · 2021Article
- Non-IgE- or Mixed IgE/Non-IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis.Nutrients · 2021Review
- Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis.Frontiers in immunology · 2021Review
- Eosinophilic Esophagitis as a Side Effect of Food Oral Immunotherapy.Medicina (Kaunas, Lithuania) · 2020Review
- Article
- Aiming for a shorter time to diagnosis: pediatric eosinophilic esophagitis in British Columbia.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications.Clinical reviews in allergy & immunology · 2019Review
- Eosinophilic esophagitis during sublingual and oral allergen immunotherapy.Current opinion in allergy and clinical immunology · 2019Review
- Immunology of the ancestral differences in eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf) as a peak value in one or more of at least four specimens obtained randomly from the esophagus. Most of the patients affected by EoE have other atopic diseases such as allergic rhinitis, asthma, IgE-mediated food allergies, and/or atopic dermatitis. The local inflammation is a T helper type 2 (Th2) flogosis, which most likely is driven by a mixed IgE and non-IgE-mediated reaction to food and/or environmental allergens. Recently published genetic studies showed also that EoE is associated with single nucleotide polymorphism (SNP) on genes which are important in atopic inflammation such as thymic stromal lymphopoietin (TSLP) located close to the Th2 cytokine cluster (IL-4, IL-5, IL-13) on chromosome 5q22. When the EoE diagnosis is made, it is imperative to control the local eosinophilic inflammation not only to give symptomatic relief to the patient but also to prevent complications such as esophageal stricture and food impaction. EoE is treated like many other atopic diseases with a combination of topical steroids and/or food antigen avoidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.