ArticleSchizophrenia bulletin2016
Aberrant Salience Is Related to Dysfunctional Self-Referential Processing in Psychosis.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity.Schizophrenia bulletin · 2018Pooled it
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- Altered processing of self-produced sensations in psychosis at cortical and spinal levels.Molecular psychiatry · 2025Article
- Correction.Current topics in behavioral neurosciences · 2025Article
- Reward processing deficits: weakened self-reward association in individuals with methamphetamine addiction undergoing abstinence.Frontiers in psychology · 2025Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Aberrant salience in acute versus chronic schizophrenia: Do medication and positive symptoms make a difference?Indian journal of psychiatry · 2024Article
- Overshadowing and salience attribution in relation to cannabis use.Schizophrenia research. Cognition · 2024Article
- Examining Neural Connectivity in Schizophrenia Using Task-Based EEG: A Graph Theory Approach.Sensors (Basel, Switzerland) · 2023Article
- Learning without contingencies: A loss of synergy between memory and reward circuits in schizophrenia.Schizophrenia research · 2023Article
- Spurious Autobiographical Memory of Psychosis: A Mechanistic Hypothesis for the Resolution, Persistence, and Recurrence of Positive Symptoms in Psychotic Disorders.Brain sciences · 2023Article
- Widespread Intra- and Inter-Network Dysconnectivity among Large-Scale Resting State Networks in Schizophrenia.Journal of clinical medicine · 2023Article
- Social Touch Reduces Pain Perception-An fMRI Study of Cortical Mechanisms.Brain sciences · 2023Article
- Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum.Brain : a journal of neurology · 2023Article
- Interactions between the cortical midline structures and sensorimotor network track maladaptive self-beliefs in clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Delusional parasitosis as premotor symptom of parkinson's disease: A case report.World journal of clinical cases · 2022Article
- The Thought From the Machine: Neural Basis of Thoughts With a Coherent and Diminished Sense of Authorship.Schizophrenia bulletin · 2021Article
- Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States-A Systematic Review of fMRI Studies.Journal of clinical medicine · 2021Review
- Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis.Frontiers in psychiatry · 2021Article
- Rationale, Relevance, and Limits of Stress-Induced Psychopathology in Rodents as Models for Psychiatry Research: An Introductory Overview.International journal of molecular sciences · 2020Review
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Authors and funding
11 authors.
Funding
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Abstract
backgroundA dysfunctional differentiation between self-relevant and irrelevant information may affect the perception of environmental stimuli as abnormally salient. The aberrant salience hypothesis assumes that positive symptoms arise from an attribution of salience to irrelevant stimuli accompanied by the feeling of self-relevance. Self-referential processing relies on the activation of cortical midline structures which was demonstrated to be impaired in psychosis. We investigated the neural correlates of self-referential processing, aberrant salience attribution, and the relationship between these 2 measures across the psychosis continuum.
methodsTwenty-nine schizophrenia patients, 24 healthy individuals with subclinical delusional ideation, and 50 healthy individuals participated in this study. Aberrant salience was assessed behaviorally in terms of reaction times to task irrelevant cues. Participants performed a self-reference task during fMRI in which they had to apply neutral trait words to them or to a public figure. The correlation between self-referential processing and aberrant salience attribution was tested.
resultsSchizophrenia patients displayed increased aberrant salience attribution compared with healthy controls and individuals with subclinical delusional ideation, while the latter exhibited intermediate aberrant salience scores. In the self-reference task, schizophrenia patients showed reduced activation in the ventromedial prefrontal cortex (vmPFC), but individuals with subclinical delusional ideation did not differ from healthy controls. In schizophrenia patients, vmPFC activation correlated negatively with implicit aberrant salience attribution.
conclusionsHigher aberrant salience attribution in schizophrenia patients is related to reduced vmPFC activation during self-referential judgments suggesting that aberrant relevance coding is reflected in decreased neural self-referential processing as well as in aberrant salience attribution.
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