ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015
Nocturnal Hypoxemia Is Associated with White Matter Hyperintensities in Patients with a Minor Stroke or Transient Ischemic Attack.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Obstructive sleep apnea and cerebral white matter change: a systematic review and meta-analysis.Journal of neurology · 2018Pooled it
- Distributed Precision Stroke Care: Artificial Intelligence-Driven Stroke Management Using Multimodal Sensor Data.Stroke · 2026Review
- Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults.Neurology · 2025Observational
- Sleep Apnea and Stroke: A Narrative Review.Chest · 2024Review
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Association of Polysomnographic Sleep Parameters With Neuroimaging Biomarkers of Cerebrovascular Disease in Older Adults With Sleep Apnea.Neurology · 2023Article
- Sleep-Disordered Breathing and Prognosis after Ischemic Stroke: It Is Not Apnea-Hypopnea Index That Matters.Diagnostics (Basel, Switzerland) · 2023Article
- COVID-19 severity is related to poor executive function in people with post-COVID conditions.Journal of neurology · 2023Article
- Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy.Journal of clinical medicine · 2023Article
- Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke.Sleep & breathing = Schlaf & Atmung · 2022Observational
- Obstructive sleep apnea and white matter hyperintensities: correlation or causation?Brain imaging and behavior · 2022Article
- Associations of sleep apnea risk and oxygen desaturation indices with cerebral small vessel disease burden in patients with stroke.Frontiers in neurology · 2022Article
- Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany.JAMA network open · 2021Article
- Obstructive Sleep Apnea and the Brain: a Focus on Gray and White Matter Structure.Current neurology and neuroscience reports · 2021Review
- High-flow nasal cannula ventilation therapy for obstructive sleep apnea in ischemic stroke patients requiring nasogastric tube feeding: a preliminary study.Scientific reports · 2020Article
- Article
- The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients.Metabolic brain disease · 2018Article
- Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure.Brain and behavior · 2018Observational
- Obstructive sleep apnea and stroke.Sleep medicine and disorders : international journal · 2018Article
- Hypoxia after stroke: a review of experimental and clinical evidence.Experimental & translational stroke medicine · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is a risk factor for stroke, which is modulated by accompanying nocturnal hypoxemia. White matter hyperintensities (WMH) share many of the same risk factors as stroke. The purpose of this study was to investigate whether OSA and nocturnal hypoxemia are associated with white matter disease in patients with minor stroke and transient ischemic attack.
methodsPatients with minor stroke or TIA were recruited. Level 3 diagnostic sleep testing was used to diagnose OSA and quantify nocturnal hypoxemia. Significant OSA was defined as respiratory disturbance index ≥ 15, and nocturnal hypoxemia was defined as oxyhemoglobin saturation < 90% for ≥ 12% of total monitoring time. WMH were assessed and quantified on FLAIR MRI. The volume of WMH was compared between those with and without significant OSA and between those with and without nocturnal hypoxemia.
resultsOne hundred nine patients were included. Thirty-four (31%) had OSA and 37 (34%) had nocturnal hypoxemia. Total WMH volume was significantly greater in the OSA than in the non-OSA groups (p = 0.04). WMH volume was also significantly higher in the hypoxic than the non-hypoxic groups (p = 0.001). Mutivariable analysis with adjustment for age, hypertension, and diabetes showed that nocturnal hypoxemia was independently associated with WMH volume (p = 0.03) but OSA was not (p = 0.29).
conclusionsWe conclude that nocturnal hypoxemia, predominantly related to OSA, is independently associated with WMH in patients who present with minor ischemic stroke and TIA and may contribute to its pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.