Trial reportMalaria journal2015
Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation.
Trial report in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review.F1000Research · 2021Pooled it
- Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.Nature communications · 2018Pooled it
- Housing modification to prevent malaria in Uganda: an analysis of costs, willingness to pay, and equity.Malaria journal · 2025Trial
- Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial.Lancet (London, England) · 2018Trial
- A cluster randomized trial comparing deltamethrin and bendiocarb as insecticides for indoor residual spraying to control malaria on Bioko Island, Equatorial Guinea.Malaria journal · 2016Trial
- Resurgence of visceral and cutaneous leishmaniasis in Kajiado County, Kenya: A coordinated response and entomological survey.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026Article
- Lagged effect of temperature and rainfall on malaria incidence in Colombia (2013-2023): An approach with Bayesian spatiotemporal adjustment.PLOS global public health · 2026Article
- Managing insecticide resistance in malaria vectors in Africa: case studies from Cameroon, Côte d'Ivoire and Tanzania.Malaria journal · 2025Article
- Cost effectiveness of malaria vector control activities in Sudan.Malaria journal · 2024Article
- Pyrethroid resistance and gene expression profile of a new resistantWellcome open research · 2024Article
- Video augmentation of the WHO cone assay to quantify mosquito behavioural responses to insecticide-treated nets.Parasites & vectors · 2023Article
- East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda.The American journal of tropical medicine and hygiene · 2022Review
- Intensity of insecticide resistance in the major malaria vector Anopheles funestus from Chikwawa, rural Southern Malawi.Parasites & vectors · 2022Article
- Patterns ofPathogens (Basel, Switzerland) · 2022Article
- The use of islands and cluster-randomized trials to investigate vector control interventions: a case study on the Bijagós archipelago, Guinea-Bissau.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- The fabric of life: what if mosquito nets were durable and widely available but insecticide-free?Malaria journal · 2020Review
- Lessons learned, challenges and outlooks for decision-making after a decade of experience monitoring the impact of indoor residual spraying in Benin, West Africa.Malaria journal · 2020Article
- Second WIN International Conference on "Integrated approaches and innovative tools for combating insecticide resistance in vectors of arboviruses", October 2018, Singapore.Parasites & vectors · 2019Article
- The relationship between insecticide resistance, mosquito age and malaria prevalence in Anopheles gambiae s.l. from Guinea.Scientific reports · 2019Article
- Patterns of anopheline feeding/resting behaviour and Plasmodium infections in North Cameroon, 2011-2014: implications for malaria control.Parasites & vectors · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 15 institutions in 9 countries.
Funding
Abstract
backgroundProgress in reducing the malaria disease burden through the substantial scale up of insecticide-based vector control in recent years could be reversed by the widespread emergence of insecticide resistance. The impact of insecticide resistance on the protective effectiveness of insecticide-treated nets (ITN) and indoor residual spraying (IRS) is not known. A multi-country study was undertaken in Sudan, Kenya, India, Cameroon and Benin to quantify the potential loss of epidemiological effectiveness of ITNs and IRS due to decreased susceptibility of malaria vectors to insecticides. The design of the study is described in this paper.
methodsMalaria disease incidence rates by active case detection in cohorts of children, and indicators of insecticide resistance in local vectors were monitored in each of approximately 300 separate locations (clusters) with high coverage of malaria vector control over multiple malaria seasons. Phenotypic and genotypic resistance was assessed annually. In two countries, Sudan and India, clusters were randomly assigned to receive universal coverage of ITNs only, or universal coverage of ITNs combined with high coverage of IRS. Association between malaria incidence and insecticide resistance, and protective effectiveness of vector control methods and insecticide resistance were estimated, respectively.
resultsCohorts have been set up in all five countries, and phenotypic resistance data have been collected in all clusters. In Sudan, Kenya, Cameroon and Benin data collection is due to be completed in 2015. In India data collection will be completed in 2016. DISCUSSION: The paper discusses challenges faced in the design and execution of the study, the analysis plan, the strengths and weaknesses, and the possible alternatives to the chosen study design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.