ArticlePlant cell reports2015
Mutations in the three Arabidopsis genes that encode the E2 subunit of the mitochondrial pyruvate dehydrogenase complex differentially affect enzymatic activity and plant growth.
Article in Plant cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response.Science advances · 2024Article
- TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots.Frontiers in plant science · 2024Article
- The diversity of substrates for plant respiration and how to optimize their use.Plant physiology · 2023Review
- Identification of Genetic Variations and Candidate Genes Responsible for Stalk Sugar Content and Agronomic Traits in Fresh Corn via GWAS across Multiple Environments.International journal of molecular sciences · 2022Article
- Non-Catalytic Subunits Facilitate Quaternary Organization of Plastidic Acetyl-CoA Carboxylase.Plant physiology · 2020Article
- Mitochondrial Pyruvate Dehydrogenase Contributes to Auxin-Regulated Organ Development.Plant physiology · 2019Article
- Translocase of the Outer Mitochondrial Membrane 40 Is Required for Mitochondrial Biogenesis and Embryo Development inFrontiers in plant science · 2019Article
- Overexpressing the H-protein of the glycine cleavage system increases biomass yield in glasshouse and field-grown transgenic tobacco plants.Plant biotechnology journal · 2019Article
- Relative quantification of phosphoproteomic changes in grapevine (Vitis vinifera L.) leaves in response to abscisic acid.Horticulture research · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
key messageThree members of the E2 subunit of the Arabidopsis mitochondrial pyruvate dehydrogenase (mtPDC) complex differentially affect mtPDC activity and plant growth. In all organisms, the mitochondrial pyruvate dehydrogenase complex (mtPDC) consists of three components: E1, E2, and E3. In this multi-enzyme complex, the E2 subunits form the core structure. In Arabidopsis, the E2 subunits are encoded by three genes: mtE2-1, mtE2-2, and mtE2-3. The contribution of each mtE2 gene to total mtPDC activity, however, is unknown. In this study, we show that knockdown of the expression of the mtE2-1 gene to 17% of that in the wild type has only a slight effect on plant growth whereas knockout of mtE2-2 leads to an embryo-lethal phenotype. The nearly null mutation of mtE2-3 does not cause any developmental abnormality. Based on these results, we conclude that mtE2-2 plays a major role in determining the total activity of the mtPDC in Arabidopsis while mtE2-1 and mtE2-3 are more or less functionally redundant with mtE2-2 under normal growth condition. Our results provide genetic evidence for a recently proposed novel mechanism that regulates plant mtPDC activity.
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