ReviewEndocrinology and metabolism (Seoul, Korea)2015
Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies.
Review in Endocrinology and metabolism (Seoul, Korea), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Genetic Determinants of Microvascular Complications of Type 1 Diabetes Mellitus: New Data from a Replication Study.Biomedicines · 2026Article
- A Cross-Sectional Comparative Study of Retinal Findings in Diabetic and Non-diabetic Chronic Kidney Disease Patients.Cureus · 2025Article
- Genetics of diabetes.World journal of diabetes · 2023Review
- Article
- Precision medicine in diabetes prevention, classification and management.Journal of diabetes investigation · 2018Review
- Diabetic polyneuropathy, deep white matter lesions, and carotid atherosclerosis: is there any association?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Normoalbuminuric diabetic kidney disease.Frontiers of medicine · 2017Review
- Biomarkers of Diabetic Retinopathy.Current diabetes reports · 2016Review
- The (CTG)The Indian journal of medical research · 2016Article
- Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Observational
- Biomarkers in Diabetic Retinopathy.The review of diabetic studies : RDSReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation. Recently, genome-wide association studies (GWASs) have identified genetic risk factors for diabetic microvascular complications of retinopathy, nephropathy, and neuropathy. We summarized the recent findings of GWASs on diabetic microvascular complications and highlighted the challenges and our opinion on future directives. Five GWASs were conducted on diabetic retinopathy, nine on nephropathy, and one on neuropathic pain. The majority of recent GWASs were underpowered and heterogeneous in terms of study design, inclusion criteria and phenotype definition. Therefore, few reached the genome-wide significance threshold and the findings were inconsistent across the studies. Recent GWASs provided novel information on genetic risk factors and the possible pathophysiology of diabetic microvascular complications. However, further collaborative efforts to standardize phenotype definition and increase sample size are necessary for successful genetic studies on diabetic microvascular complications.
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