ArticlePloS one2015
The Ages and Stages Questionnaire and Neurodevelopmental Impairment in Two-Year-Old Preterm-Born Children.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02621645 (Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence), which is not on this map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence: an Open-label Randomized Controlled Trial: TRAPIST - TRAP Intervention STudy
Who cites it
20 citing papers in PubMed.
- The SAVE FGR study: Short term variation Analysis versus Visual Evaluation of cardiotocography in early-onset Fetal Growth Restriction to trigger expedited birth - study protocol for a stepped wedge cluster randomized trial.BMC pregnancy and childbirth · 2026Trial
- Randomized trial of azithromycin to eradicate Ureaplasma respiratory colonization in preterm infants: 2-year outcomes.Pediatric research · 2022Trial
- Stability of developmental status and risk of impairment at 24 and 36 months in late preterm infants.Infant behavior & development · 2020Trial
- Neurodevelopmental assessment at 24 months in infants with esophageal atresia: A prospective cohort study.Journal of pediatric gastroenterology and nutrition · 2026Article
- Systemic inflammatory mediators and neurodevelopmental outcomes in term infants: a retrospective cohort study.BMC pediatrics · 2026Article
- Measuring child development at the 2-2½-year health and development review in England: a rapid scoping review of available tools.BMJ open · 2026Article
- Article
- Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Prenatal maternal diabetes, comorbidities, and risk for neurodevelopmental impairment in the first two years.Pediatric research · 2025Article
- Effects of two-stage preterm formulas on growth, nutritional biomarkers, and neurodevelopment in preterm infants.Frontiers in pediatrics · 2024Article
- Neurodevelopmental Outcome at Corrected Age of 2 Years among Children Born Preterm with Operative Vaginal Delivery: A Population-Based Study (LIFT Cohort).Journal of clinical medicine · 2023Article
- Serial neuroimaging of brain growth and development in very preterm infants receiving tailored neuropromotive support in the NICU. Protocol for a prospective cohort study.Frontiers in pediatrics · 2023Article
- Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait.BMC pediatrics · 2022Article
- Article
- The Association between the Five-Minute Apgar Score and Neurodevelopmental Outcomes among Children Aged 8-66 Months in Australia.International journal of environmental research and public health · 2021Article
- Targeting human milk fortification to improve very preterm infant growth and brain development: study protocol for Nourish, a single-center randomized, controlled clinical trial.BMC pediatrics · 2021Article
- The Association of Vitamin D and Neurodevelopmental Status Among 2 Years Old Infants.Global pediatric health · 2021Article
- Adapting the Ages and Stages Questionnaire to Identify and Quantify Development Among Children With Evidence of Zika Infection.Infants and young children · 2020Article
- "STEP", an early developmental screening tool that predicts one-year outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study.BMJ (Clinical research ed.) · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the ability of the Ages and Stages Questionnaire, Third Edition (ASQ3) to help identify or exclude neurodevelopmental impairment (NDI) in very preterm-born children at the corrected age of two.
methodsWe studied the test results of 224 children, born at <32 postmenstrual weeks, who had scores on ASQ3 and Bayley Scales of Infant and Toddler Development, Third Edition (BSIDIII) and neurological examination at 22-26 months' corrected age. We defined NDI as a score of <70 on the cognitive--or motor composite scale of BSIDIII, or impairment on neurological examination or audiovisual screening. We compared NDI with abnormal ASQ3 scores, i.e., < -2SDs on any domain, and with ASQ3 total scores. To correct for possible overestimation of BSIDIII, we also analyzed the adjusted BSIDIII thresholds for NDI, i.e., scores <80 and <85.
resultsWe found 61 (27%) children with abnormal ASQ3 scores, and 10 (4.5%) children who had NDI with original BSIDIII thresholds (<70). Twelve children had NDI at BSIDIII thresholds at <80, and 15 had <85. None of the 163 (73%) children who passed ASQ3 had NDI. The sensitivity of ASQ3 to detect NDI was excellent (100%), its specificity was acceptable (76%), and its negative predictive value (NPV) was 100%. Sensitivity and NPV remained high with the adjusted BSIDIII thresholds.
conclusionThe Ages and Stages Questionnaire is a simple, valid and cost-effective screening tool to help identify and exclude NDI in very preterm-born children at the corrected age of two years.
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