ReviewAngewandte Chemie (International ed. in English)2015
Machine-Assisted Organic Synthesis.
Review in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery.Medicinal research reviews · 2026Review
- Carrier-Free Enzyme Immobilization for High-Density Catalytic Architectures in Flow Biocatalysis.JACS Au · 2026Review
- Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities.Organic process research & development · 2026Article
- Continuous-flow carbonyl hydrogenation under subatmospheric to atmospheric hydrogen pressure enabled by robust heterogeneous Pt-Fe catalysts.Beilstein journal of organic chemistry · 2026Article
- Co(II)-Mediated Catalytic Chain Transfer Polymerization (CCTP) Carried Out Under Flow Reaction Conditions and Introducing a New Method for Online GPC Monitoring.ACS polymers Au · 2025Article
- Advanced Electroanalysis for Electrosynthesis.ACS organic & inorganic Au · 2024Review
- Robotic Modules for the Programmable Chemputation of Molecules and Materials.ACS central science · 2023Review
- Ex-situ generation and synthetic utilization of bare trifluoromethyl anion in flow via rapid biphasic mixing.Nature communications · 2023Article
- Progress of Artificial Intelligence in Drug Synthesis and Prospect of Its Application in Nitrification of Energetic Materials.Molecules (Basel, Switzerland) · 2023Review
- Towards Antibiotic Synthesis in Continuous-Flow Processes.Molecules (Basel, Switzerland) · 2023Review
- Microflow chemistry and its electrification for sustainable chemical manufacturing.Chemical science · 2022Review
- Understanding flow chemistry for the production of active pharmaceutical ingredients.iScience · 2022Review
- Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors.ACS central science · 2022Article
- Data-Centric Architecture for Self-Driving Laboratories with Autonomous Discovery of New Nanomaterials.Nanomaterials (Basel, Switzerland) · 2021Article
- Continuous Flow Synthesis of Anticancer Drugs.Molecules (Basel, Switzerland) · 2021Review
- An integrated console for capsule-based, automated organic synthesis.Chemical science · 2021Article
- Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds.International journal of molecular sciences · 2021Review
- Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines.RSC medicinal chemistry · 2020Article
- Automated Solution-Phase Synthesis ofOrganic letters · 2020Article
- Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow.ACS omega · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this Review we describe how the advent of machines is impacting on organic synthesis programs, with particular emphasis on the practical issues associated with the design of chemical reactors. In the rapidly changing, multivariant environment of the research laboratory, equipment needs to be modular to accommodate high and low temperatures and pressures, enzymes, multiphase systems, slurries, gases, and organometallic compounds. Additional technologies have been developed to facilitate more specialized reaction techniques such as electrochemical and photochemical methods. All of these areas create both opportunities and challenges during adoption as enabling technologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.