ArticleInternational journal of environmental research and public health2015
Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Integrated Metabolomic and Transcriptomic Analyses of Anthocyanin Synthesis During Fruit Development inBiology · 2025Article
- The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.Protoplasma · 2025Article
- High-quality genome of black wolfberry (Horticulture research · 2025Article
- Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models.Frontiers in pharmacology · 2024Article
- Black Goji Berry (Nutrients · 2023Review
- Germplasm Resources and Strategy for Genetic Breeding ofFrontiers in plant science · 2022Review
- Article
- Article
- Review of the Efficacy and Mechanisms of Traditional Chinese Medicines as a Therapeutic Option for Ionizing Radiation Induced Damage.Frontiers in pharmacology · 2021Review
- Fruit ripening in Lycium barbarum and Lycium ruthenicum is associated with distinct gene expression patterns.FEBS open bio · 2020Article
- Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice.Food science & nutrition · 2020Article
- Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening.Scientific reports · 2020Article
- Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats.Frontiers in pharmacology · 2019Article
- Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.Oxidative medicine and cellular longevity · 2016Article
- Carbon Ion Irradiated Neural Injury Induced the Peripheral Immune Effects in Vitro or in Vivo.International journal of molecular sciences · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protective effect of Lycium ruthenicum Murr. against radiation injury was examined in mice. Kunming mice were randomly divided into a control group, model group, positive drug group and L. ruthenicum high dose (8 g/kg), L. ruthenicum middle dose (4 g/kg), L. ruthenicum low dose (2 g/kg) treatment groups, for which doses were administered the third day, seventh day and 14th day after irradiation. L. ruthenicum extract was administered orally to the mice in the three treatment groups and normal saline was administered orally to the mice in the control group and model group for 14 days. The positive group was treated with amifostine (WR-2721) at 30 min before irradiation. Except for the control group, the groups of mice received a 5 Gy quantity of X-radiation evenly over their whole body at one time. Body weight, hemogram, thymus and spleen index, DNA, caspase-3, caspase-6, and P53 contents were observed at the third day, seventh day, and 14th day after irradiation. L. ruthenicum could significantly increase the total red blood cell count, hemoglobin count and DNA contents (p < 0.05). The spleen index recovered significantly by the third day and 14th day after irradiation (p < 0.05). L. ruthenicum low dose group showed a significant reduction in caspase-3 and caspase-6 of serum in mice at the third day, seventh day, and 14th day after irradiation and L. ruthenicum middle dose group experienced a reduction in caspase-6 of serum in mice by the seventh day after irradiation. L. ruthenicum could decrease the expression of P53. The results showed that L. ruthenicum had protective effects against radiation injury in mice.
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