ArticleInternational journal of environmental research and public health2015
Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Lower Striatal Dopamine D2 Receptor Availability in Individuals Who Test Positive for Quantitated Urine Metabolites of Tobacco and/or Marijuana Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Using Indocyanine Green Fluorescence Angiography to Evaluate the Impact of Surgical and Patient Factors on Posterior Septal Artery Perfusion in Endoscopic Skull Base Surgery.Journal of neurological surgery. Part B, Skull base · 2025Article
- Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index.NPJ dementia · 2025Article
- Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population.Cerebral circulation - cognition and behavior · 2025Article
- Pro-atherogenic medical conditions are associated with widespread regional brain metabolite abnormalities in those with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Resting-state functional connectivity and structural differences between smokers and healthy non-smokers.Scientific reports · 2024Article
- Effects of electronic cigarette E-liquid and device wattage on vascular function.Toxicology and applied pharmacology · 2023Article
- Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study.The American journal of drug and alcohol abuse · 2023Article
- Association of Income with Post-Stroke Cognition and the Underlying Neuroanatomical Mechanism.Brain sciences · 2023Article
- PheSom: a term frequency-based method for measuring human phenotype similarity on the basis of MeSH vocabulary.Frontiers in genetics · 2023Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Precision Preventive Medicine of Relapse in Smoking Cessation: Can MRI Inform the Search of Intermediate Phenotypes?Biology · 2021Review
- Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span.Scientific reports · 2021Article
- The Influence of Recreational Substance Use in TMS Research.Brain sciences · 2020Review
- Medical Conditions Linked to Atherosclerosis Are Associated With Magnified Cortical Thinning in Individuals With Alcohol Use Disorders.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Article
- Cigarette smoking history is associated with poorer recovery in multiple neurocognitive domains following treatment for an alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2020Article
- Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients.Frontiers in aging neuroscience · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic cigarette smoking is associated with numerous abnormalities in brain neurobiology, but few studies specifically investigated the chronic effects of smoking (compared to the acute effects of smoking, nicotine administration, or nicotine withdrawal) on cerebral perfusion (i.e., blood flow). Predominately middle-aged male (47 ± 11 years of age) smokers (n = 34) and non-smokers (n = 27) were compared on regional cortical perfusion measured by continuous arterial spin labeling magnetic resonance studies at 4 Tesla. Smokers showed significantly lower perfusion than non-smokers in the bilateral medial and lateral orbitofrontal cortices, bilateral inferior parietal lobules, bilateral superior temporal gyri, left posterior cingulate, right isthmus of cingulate, and right supramarginal gyrus. Greater lifetime duration of smoking (adjusted for age) was related to lower perfusion in multiple brain regions. The results indicated smokers showed significant perfusion deficits in anterior cortical regions implicated in the development, progression, and maintenance of all addictive disorders. Smokers concurrently demonstrated reduced blood flow in posterior brain regions that show morphological and metabolic aberrations as well as elevated beta amyloid deposition demonstrated by those with early stage Alzheimer disease. The findings provide additional novel evidence of the adverse effects of cigarette smoking on the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.