ArticleeLife2015
Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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73 citing papers in PubMed.
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- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- A neural connectivity atlas for fly flight control.Current biology : CB · 2026Article
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- Gut hormone signaling drives sex differences in metabolism and behavior.Molecular metabolism · 2026Article
- An entropic measure of diverse specialization highlights multifunctional neurons in annotated connectomes.Network neuroscience (Cambridge, Mass.) · 2026Article
- A new system for studying neuronal remodeling and its relation to behavior in Drosophila.Communications biology · 2025Article
- Fer3 is uniquely expressed in NotchOFF hemilineages, where it promotes interneuron identity.Development (Cambridge, England) · 2025Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
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- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- A library of lineage-specific driver lines connects developing neuronal circuits to behavior in theeLife · 2025Article
- Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex.bioRxiv : the preprint server for biology · 2025Article
- Neural connectivity of a computational map for fly flight control.bioRxiv : the preprint server for biology · 2025Article
- Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.Nature communications · 2025Article
- Examining the vulnerability of adult neuron subtypes to tau-mediated toxicity in Drosophila.Translational psychiatry · 2025Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
13 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Drosophila central neurons arise from neuroblasts that generate neurons in a pair-wise fashion, with the two daughters providing the basis for distinct A and B hemilineage groups. 33 postembryonically-born hemilineages contribute over 90% of the neurons in each thoracic hemisegment. We devised genetic approaches to define the anatomy of most of these hemilineages and to assessed their functional roles using the heat-sensitive channel dTRPA1. The simplest hemilineages contained local interneurons and their activation caused tonic or phasic leg movements lacking interlimb coordination. The next level was hemilineages of similar projection cells that drove intersegmentally coordinated behaviors such as walking. The highest level involved hemilineages whose activation elicited complex behaviors such as takeoff. These activation phenotypes indicate that the hemilineages vary in their behavioral roles with some contributing to local networks for sensorimotor processing and others having higher order functions of coordinating these local networks into complex behavior.
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