ArticleObesity (Silver Spring, Md.)2015
Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04302168 (Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus), which is not on this map. Cited by 85 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Effects of high-fat diets on fetal growth in rodents: a systematic review.Reproductive biology and endocrinology : RB&E · 2019Pooled it
- A high-fat, high-sugar diet impairs maternal metabolism throughout pregnancy and lactation in mice.The Journal of physiology · 2026Article
- Maternal obesity decreases offspring lifespan.Molecular metabolism · 2026Article
- Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences.Cells · 2026Review
- Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study.Translational psychiatry · 2025Article
- PiggyBac transposase-mediated inducible trophoblast-specific knockdown of Mtor decreases placental nutrient transport and fetal growth.Clinical science (London, England : 1979) · 2025Article
- Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies.International journal of molecular sciences · 2025Review
- Maternal Adiponectin Decreases Placenta Nutrient Transport in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice.Acta physiologica (Oxford, England) · 2025Article
- Lentivirus-Mediated Trophoblast-Specific Deptor Knockdown Increases Transplacental System A and System L Amino Acid Transport and Fetal Growth in Mice.Function (Oxford, England) · 2025Article
- Trophoblast-specific overexpression of adiponectin receptor 2 causes fetal growth restriction in pregnant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.Nutrients · 2024Review
- Regulation of placental amino acid transport in health and disease.Acta physiologica (Oxford, England) · 2024Review
- Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice.PNAS nexus · 2024Article
- Inflammation as a Sex-Specific Mediator in the Relationship between Maternal and Offspring Obesity in C57Bl/6J Mice.Biology · 2024Article
- Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations.Cellular and molecular life sciences : CMLS · 2024Article
- Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit.Scientific reports · 2024Article
- Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring.Journal of neuroinflammation · 2024Article
- Childhood obesity from the genes to the epigenome.Frontiers in endocrinology · 2024Review
- Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling.Clinical science (London, England : 1979) · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo identify possible mechanisms linking obesity in pregnancy to increased fetal adiposity and growth, a unique mouse model of maternal obesity associated with fetal overgrowth was developed, and the hypothesis that maternal obesity causes up-regulation of placental nutrient transporter expression and activity was tested.
methodsC57BL/6J female mice were fed a control (C) or a high-fat/high-sugar (HF/HS) pelleted diet supplemented by ad libitum access to sucrose (20%) solution, mated, and studied at embryonic day 18.5.
resultsHF/HS diet increased maternal fat mass by 2.2-fold (P < 0.01) and resulted in glucose intolerance with normal fasting glucose. Maternal circulating insulin, leptin, and cholesterol were increased (P < 0.05) whereas total and high-molecular-weight adiponectin was decreased (P < 0.05). HF/HS diet increased fetal weight (+18%, P = 0.0005). In trophoblast plasma membranes (TPM) isolated from placentas of HF/HS-fed animals, protein expression of glucose transporter (GLUT) 1 and 3, sodium-coupled neutral amino acid transporter (SNAT) 2, and large neutral amino acid transporter 1 (LAT1) was increased. TPM System A and L amino acid transporter activity was increased in the HF/HS group.
conclusionsUp-regulation of specific placental nutrient transporter isoforms may constitute a mechanism underlying fetal overgrowth in maternal obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.