Trial reportObesity (Silver Spring, Md.)2015
Energy intake, nonexercise physical activity, and weight loss in responders and nonresponders: The Midwest Exercise Trial 2.
Trial report in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Exercise Training on Non-Exercise Physical Activity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Compensatory mechanisms from different exercise intensities in type 2 diabetes: a secondary analysis of a 1-year randomized controlled trial.Acta diabetologica · 2023Trial
- Trial
- Dose-response effects of aerobic exercise on energy compensation in postmenopausal women: combined results from two randomized controlled trials.International journal of obesity (2005) · 2017Trial
- Randomized trial reveals that physical activity and energy expenditure are associated with weight and body composition after RYGB.Obesity (Silver Spring, Md.) · 2017Trial
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Why did Bob stop losing weight? We need to talk about energy expenditure compensation.Biology letters · 2025Article
- Exploring Strategies to Promote Exercise as a Viable Obesity and Chronic Disease Treatment.Nutrients · 2025Review
- The associations between physical activity, microbiome and metabolic adaptation in sedentary overweight adults.Frontiers in nutrition · 2025Article
- The role of physical activity in the regulation of body weight: The overlooked contribution of light physical activity and sedentary behaviors.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Article
- Altered motivation states for physical activity and 'appetite' for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss.Frontiers in psychology · 2023Article
- Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight-loss intervention: A pilot study.Obesity (Silver Spring, Md.) · 2022Article
- The Niche of n-of-1 Trials in Precision Medicine for Weight Loss and Obesity Treatment: Back to the Future.Current nutrition reports · 2022Review
- Compensatory effects of different exercise durations on non-exercise physical activity, appetite, and energy intake in normal weight and overweight adults.Frontiers in physiology · 2022Article
- Metabolic effects of high-intensity interval training and essential amino acids.European journal of applied physiology · 2021Article
- Examining the Role of Exercise Timing in Weight Management: A Review.International journal of sports medicine · 2021Review
- Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention.Obesity (Silver Spring, Md.) · 2021Article
- Observational
- Variability in Individual Response to Aerobic Exercise Interventions Among Older Adults.Journal of aging and physical activity · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo compare energy intake, total daily energy expenditure (TDEE), nonexercise energy expenditure (NEEx), resting metabolic rate (RMR), nonexercise physical activity (NEPA), and sedentary time between participants with weight loss <5% (nonresponders) vs. ≥5% (responders) in response to exercise.
methodsAdults (18-30 years) with overweight/obesity (BMI 25-40 kg/m(2) ) were randomized to exercise: 5 days/week, 400 or 600 kcal/session, 10 months.
resultsOf the participants, 40 responded and 34 did not respond to the exercise protocol. Nonresponder energy intake was higher vs. responders, significant only in men (P=0.034). TDEE increased only in responders (P=0.001). NEEx increased in responders and decreased in nonresponders, significant only in men (P=0.045). There were no within- or between-group differences for change in RMR. NEPA increased in responders and decreased in nonresponders (group-by-time interactions: total sample, P=0.049; men, P=0.016). Sedentary time decreased in both groups, significant only in men.
conclusionsMen who did not lose weight in response to exercise (<5%) had higher energy intake and lower NEEx when compared with men losing ≥5%. No significant differences in any parameters assessed were observed between women who lost <5% vs. those losing ≥5%. Factors associated with the weight loss response to exercise in women warrant additional investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.