Evidence map›Paper›PMID 26192904›Full record

Trial reportJournal of veterinary internal medicine

Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head.

E P Spugnini, M Pizzuto, M Filipponi, L Romani, B Vincenzi, F Menicagli, A Lanza, R De Girolamo, R Lomonaco, M Fanciulli and 2 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

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  15. Article
  16. Electrochemotherapy palliation of an oral squamous cell carcinoma in an African hedgehog (Veterinary research forum : an international quarterly journal · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

E P SpugniniSAFU, Regina Elena Cancer Institute, Rome, Italy.
M PizzutoCentro Veterinario Gianicolense, Rome, Italy.
M FilipponiCentro Veterinario Casal Monastero, Rome, Italy.
L RomaniCentro Veterinario Casal Monastero, Rome, Italy.
B VincenziMedical Oncology, University Campus Bio-Medico, Rome, Italy.
F MenicagliCentro Veterinario Gianicolense, Rome, Italy.
A LanzaCentro Veterinario Gianicolense, Rome, Italy.
R De GirolamoCentro Veterinario Gianicolense, Rome, Italy.
R LomonacoAmbulatorio Veterinario Dr. Lomonaco, Rome, Italy.
M FanciulliSAFU, Regina Elena Cancer Institute, Rome, Italy.
G SprianoDepartment of Head and Neck Oncology, Regina Elena Cancer Institute, Rome, Italy.
A BaldiDepartment of Environmental Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Naples, Italy.
Veterinary Oncological Center · ITCancer Institute (WIA) · INNaples Anesthesia & Physician Associates · USUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvanced carcinoma of the head represents a substantial health problem in cats for local control and overall survival.

objectivesEvaluate the capability of electrochemotherapy (ECT) to improve bleomycin efficacy in cats with periocular carcinoma and advanced carcinoma of the head. ANIMALS: Twenty-one cats with periocular carcinoma (17 squamous cell carcinoma [SCC] and 4 anaplastic carcinoma) and 26 cats with advanced SCC of the head.

methodsNonrandomized prospective controlled study. Periocular carcinoma cohorts: 12 cats were treated with bleomycin (15 mg/m(2) i.v.) coupled with ECT under anesthesia; 9 cats were treated with bleomycin alone. Advanced head SCC cohorts: 14 cats were treated with bleomycin (15 mg/m(2) i.v.) coupled with ECT administered under sedation; 12 control cats were treated with bleomycin alone. ECT treatments (2-8) were performed every other week until complete remission (CR) or tumor progression occurred.

resultsToxicities were minimal and mostly treated symptomatically. Overall response rate in the ECT treated animals was 89% (21 Complete Response [CR] and 2 Partial Response [PR]) whereas controls had response rate of 33% (4 CR and 3 PR). Median time to progression in ECT group was 30.5 months, whereas in controls it was 3.9 months (P < .0001). Median time to progression for ECT cohorts was 24.2 months for periocular cohort and 20.6 in advanced head SCC cohort, respectively.

conclusionsElectrochemotherapy is well tolerated for advanced SCC of the head in cats; its use may be considered among loco-regional strategies for cancer therapy in sensitive body regions such as periocular region.

Indexed as

AnimalsAntibiotics, AntineoplasticBleomycinCarcinoma, Squamous CellCat DiseasesCatsElectrochemotherapyEyelid NeoplasmsFemaleHead and Neck NeoplasmsMaleSkin NeoplasmsTreatment OutcomeAntibiotics, AntineoplasticBleomycinBiphasic PulsesCarcinomaElectroporationFeline

Identifiers

PMID26192904
PMCPMC4858043
OpenAlexW1655850459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.