Evidence map›Paper›PMID 26192794›Full record

ArticleClinical journal of gastroenterology2009

Acute Epstein-Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations.

Mikio Fujiwara, Shin'ichi Miyamoto, Kouta Iguchi, Toshihiro Matsunaka, Hiromi Sakashita, Tatsuaki Tsuruyama, Hirokazu Kanegane, Hiroyuki Marusawa, Hiroshi Nakase, Tsutomu Chiba

Abstract read
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Article in Clinical journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Fine needle cytology features of an atypical presentation of infectious mononucleosis.Journal of oral and maxillofacial pathology : JOMFP · 2020
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mikio FujiwaraDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Shin'ichi MiyamotoDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan. shmiyamo@kuhp.kyoto-u.ac.jp.
Kouta IguchiDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Toshihiro MatsunakaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Hiromi SakashitaLaboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Tatsuaki TsuruyamaLaboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Hirokazu KaneganeDepartment of Pediatrics, Graduate School of Medicine, Toyama University, Toyama, Japan.
Hiroyuki MarusawaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Tsutomu ChibaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Kyoto University · JPKyoto University Hospital · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Epstein-Barr virus (EBV) infection is usually a self-limiting disease. Although it is sometimes accompanied by severe complications such as thrombocytopenia, hemolytic anemia, and splenic rupture, predominantly gastrointestinal complications are rarely reported. We studied an unusual case of primary EBV infection associated with severe hemorrhagic gastroenteritis. EBV infection was confirmed in the biopsy specimen by demonstrating the presence of EBV DNA by polymerase chain reaction, and of EBV-encoded small RNA (EBER)-positive cells by in-situ hybridization. Our patient was suspected of having primary EBV infection from the serological findings-EBV-viral capsid antigen IgM (+) and EBV nuclear antigen (-)-but he did not show typical clinical features of infectious mononucleosis such as lymph node swelling, pharyngitis, liver dysfunction, and splenomegaly. A definite diagnosis of primary EBV infection was made using biopsy specimens by demonstrating the presence of EBV DNA and EBER-positive cells.

Indexed as

EBV-encoded early small RNAEpstein–Barr virusGastroenteritisPolymerase chain reaction

Identifiers

PMID26192794
OpenAlexW2342830991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.