ArticleStem cells and development2015
Cultured Human Adipose Tissue Pericytes and Mesenchymal Stromal Cells Display a Very Similar Gene Expression Profile.
Article in Stem cells and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Pregnancy-specific glycoproteins as molecular links between mesenchymal stromal cells and M2 macrophages in tissue repair: implications for cancer progression.Frontiers in cell and developmental biology · 2026Review
- Mesenchymal "stem" cells, or facilitators for the development of regenerative macrophages? Pericytes at the interface of wound healing.Frontiers in cell and developmental biology · 2023Review
- Article
- Review
- Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential.Journal of neurology · 2021Review
- Mesenchymal Stem Cells for Neurological Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Analyses of the pericyte transcriptome in ischemic skeletal muscles.Stem cell research & therapy · 2021Article
- Review
- Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.Frontiers in cell and developmental biology · 2020Article
- Is Stem Cell Commerce in Small Animal Therapies Scientifically and Morally Justified?Stem cell reviews and reports · 2019Review
- Concise Review: Mesenchymal Stem Cells: From Roots to Boost.Stem cells (Dayton, Ohio) · 2019Review
- Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis.PloS one · 2019Article
- Prevascularization of natural nanofibrous extracellular matrix for engineering completely biological three-dimensional prevascularized tissues for diverse applications.Journal of tissue engineering and regenerative medicine · 2018Article
- Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids.Stem cells international · 2018Article
- Mesenchymal Stem Cells: Time to Change the Name!Stem cells translational medicine · 2017Article
- Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain.International journal of molecular sciences · 2017Review
- Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs.Journal of visualized experiments : JoVE · 2016Article
- Transcriptomic comparisons between cultured human adipose tissue-derived pericytes and mesenchymal stromal cells.Genomics data · 2016Article
- Article
- Patient-Specific Age: The Other Side of the Coin in Advanced Mesenchymal Stem Cell Therapy.Frontiers in physiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stromal cells (MSCs) are cultured cells that can give rise to mature mesenchymal cells under appropriate conditions and secrete a number of biologically relevant molecules that may play an important role in regenerative medicine. Evidence indicates that pericytes (PCs) correspond to mesenchymal stem cells in vivo and can give rise to MSCs when cultured, but a comparison between the gene expression profiles of cultured PCs (cPCs) and MSCs is lacking. We have devised a novel methodology to isolate PCs from human adipose tissue and compared cPCs to MSCs obtained through traditional methods. Freshly isolated PCs expressed CD34, CD140b, and CD271 on their surface, but not CD146. Both MSCs and cPCs were able to differentiate along mesenchymal pathways in vitro, displayed an essentially identical surface immunophenotype, and exhibited the ability to suppress CD3(+) lymphocyte proliferation in vitro. Microarray expression data of cPCs and MSCs formed a single cluster among other cell types. Further analyses showed that the gene expression profiles of cPCs and MSCs are extremely similar, although MSCs differentially expressed endothelial cell (EC)-specific transcripts. These results confirm, using the power of transcriptomic analysis, that PCs give rise to MSCs and suggest that low levels of ECs may persist in MSC cultures established using traditional protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.