ArticleNeuropsychology2016
A diffusion model analysis of episodic recognition in preclinical individuals with a family history for Alzheimer's disease: The adult children study.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- Age differences in diffusion model parameters: a meta-analysis.Psychological research · 2021Pooled it
- Optimizing the Color Shapes Task for Ambulatory Assessment and Drift Diffusion Modeling: A Factorial Experiment.JMIR formative research · 2025Article
- Baseline and longitudinal changes in cortical thickness and hippocampal volume predict cognitive decline.Journal of Alzheimer's disease : JAD · 2025Article
- Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle-Aged Offspring of People With Alzheimer's Disease.International journal of geriatric psychiatry · 2025Article
- The associations between attentional control, episodic memory, and Alzheimer's disease biomarkers of tau and neurodegeneration.Journal of Alzheimer's disease : JAD · 2025Article
- Non-decision time: The Higgs Boson of decision.Psychological review · 2025Article
- Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.Scientific reports · 2024Article
- Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.bioRxiv : the preprint server for biology · 2023Article
- Parsing memory and nonmemory contributions to age-related declines in mnemonic discrimination performance: a hierarchical Bayesian diffusion decision modeling approach.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Exploratory Longitudinal Study of Ocular Structural and Visual Functional Changes in Subjects at High Genetic Risk of Developing Alzheimer's Disease.Biomedicines · 2023Article
- Utility of Diffusion Modeling of Cogstate Brief Battery Test Performance in Detecting Mild Cognitive Impairment.Assessment · 2023Article
- Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease.Frontiers in human neuroscience · 2023Article
- The Effect of Ingroup vs. Outgroup Members' Behavior on Charity Preference: A Drift-Diffusion Model Approach.Frontiers in psychology · 2022Article
- Comparing Eight Parameter Estimation Methods for the Ratcliff Diffusion Model Using Free Software.Frontiers in psychology · 2020Article
- Model-based assessment and neural correlates of spatial memory deficits in mild cognitive impairment.Neuropsychologia · 2020Article
- Experimental validation of the diffusion model based on a slow response time paradigm.Psychological research · 2019Article
- Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine.Pharmacology & therapeutics · 2019Review
- Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors.eLife · 2019Article
- Item-specific processing reduces false recognition in older and younger adults: Separating encoding and retrieval using signal detection and the diffusion model.Memory & cognition · 2018Article
Corrections and comments
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5 authors.
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Abstract
objectiveA family history of Alzheimer's disease (AD) increases the risk of developing AD and can influence the accumulation of well-established AD biomarkers. There is some evidence that family history can influence episodic memory performance even in cognitively normal individuals. We attempted to replicate the effect of family history on episodic memory and used a specific computational model of binary decision making (the diffusion model) to understand precisely how family history influences cognition. Finally, we assessed the sensitivity of model parameters to family history controlling for standard neuropsychological test performance.
methodAcross 2 experiments, cognitively healthy participants from the Adult Children Study completed an episodic recognition test consisting of high- and low-frequency words. The diffusion model was applied to decompose accuracy and reaction time (RT) into latent parameters which were analyzed as a function of family history.
resultsIn both experiments, individuals with a family history of AD exhibited lower recognition accuracy and this occurred in the absence of an apolipoprotein E (APOE) ε4 allele. The diffusion model revealed this difference was due to changes in the quality of information accumulation (the drift rate) and not differences in response caution or other model parameters. This difference remained after controlling for several standard neuropsychological tests.
conclusionsThese results confirm that the presence of a family history of AD confers a subtle cognitive deficit in episodic memory as reflected by decreased drift rate that cannot be attributed to APOE. This measure may serve as a novel cognitive marker of preclinical AD.
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