ArticleCancer biology & therapy2015
Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model.
Article in Cancer biology & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02824835 (The Effect of the Plant Hormones Strigolactones on Cultures of Dysplastic Colonic Lesions and Cancer), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of the Plant Hormones Strigolactones on Cultures of Dysplastic Colonic Lesions and Cancer
Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- From plant hormones to human health: progress and challenges in strigolactone biosynthetic structural diversity and antitumor effects.Frontiers in plant science · 2026Review
- Allies or Enemies? The Power of Plant Hormones in Animals: Insights into Their Regulatory Roles.Molecules (Basel, Switzerland) · 2025Review
- Strigolactone Analogs: Two New Potential Bioactiphores for Glioblastoma.ACS chemical neuroscience · 2022Article
- Strigolactones, from Plants to Human Health: Achievements and Challenges.Molecules (Basel, Switzerland) · 2021Review
- GR24, A Synthetic Strigolactone Analog, and Light Affect the Organization of Cortical Microtubules in Arabidopsis Hypocotyl Cells.Frontiers in plant science · 2021Article
- Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection.Microorganisms · 2020Article
- Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.Analytical cellular pathology (Amsterdam) · 2019Article
- Glutathione/pH-responsive nanosponges enhance strigolactone delivery to prostate cancer cells.Oncotarget · 2018Article
- Strigolactones-a novel class of phytohormones as anti-cancer agents.Journal of pesticide science · 2018Article
- Structure-activity relationships of strigolactones via a novel, quantitative in planta bioassay.Journal of experimental botany · 2018Article
- Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle.F1000Research · 2018Article
- Strigolactones: a plant phytohormone as novel anti-inflammatory agents.MedChemComm · 2018Article
- Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair.Oncotarget · 2016Article
- Plant derived substances with anti-cancer activity: from folklore to practice.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
Abstract
Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.