ArticlePloS one2015
Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking.Nature communications · 2026Article
- Ferritin light-chain contributes to hair cells function and survival.Communications biology · 2026Article
- Functional Division of Insect Blood Cells by Single-Cell RNA-Sequencing and Cell-Type-Specific FISH Markers.Cells · 2025Article
- An efficient injection protocol forBiology methods & protocols · 2024Article
- Review
- Localization of secreted ferritin (FER2) in the embryos of the tick Haemaphysalis longicornis.Parasites & vectors · 2023Article
- Iron Homeostasis in Insects.Annual review of entomology · 2023Review
- Shotgun and TMT-Labeled Proteomic Analysis of the Ovarian Proteins of an Insect Vector, Aedes aegypti (Diptera: Culicidae).Journal of insect science (Online) · 2022Article
- The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship betweenmicroLife · 2021Article
- Cuticle darkening correlates with increased body copper content in Drosophila melanogaster.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2020Article
- A versatile toolkit for CRISPR-Cas13-based RNA manipulation in Drosophila.Genome biology · 2020Article
- Social reprogramming in ants induces longevity-associated glia remodeling.Science advances · 2020Article
- Expression analysis of glutathione S-transferases and ferritins during the embryogenesis of the tickHeliyon · 2020Article
- Loss of ferritin in developing wing cells: Apoptosis and ferroptosis coincide.PLoS genetics · 2020Article
- Iron and Ferritin Deposition in the Ovarian Tissues of the Yellow Fever Mosquito (Diptera: Culicidae).Journal of insect science (Online) · 2019Article
- Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis.PLoS genetics · 2019Article
- Ferritin regulates organismal energy balance and thermogenesis.Molecular metabolism · 2019Article
- Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit.Biological trace element research · 2019Article
- Dnmt1 is essential for egg production and embryo viability in the large milkweed bug, Oncopeltus fasciatus.Epigenetics & chromatin · 2019Article
- Impact of Autophagy and Aging on Iron Load and Ferritin inFrontiers in cell and developmental biology · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry. In larvae, ferritin accumulates in the midgut, hemolymph, garland, pericardial cells and in the nervous system. Here we present analyses of embryonic phenotypes for mutations in Fer1HCH, Fer2LCH and in both genes simultaneously. Mutations in either gene or deletion of both genes results in a similar set of cuticular embryonic phenotypes, ranging from non-deposition of cuticle to defects associated with germ band retraction, dorsal closure and head involution. A fraction of ferritin mutants have embryonic nervous systems with ventral nerve cord disruptions, misguided axonal projections and brain malformations. Ferritin mutants die with ectopic apoptotic events. Furthermore, we show that ferritin maternal contribution, which varies reflecting the mother's iron stores, is used in early development. We also evaluated phenotypes arising from the blockage of COPII transport from the endoplasmic reticulum to the Golgi apparatus, feeding the secretory pathway, plus analysis of ectopically expressed and fluorescently marked Fer1HCH and Fer2LCH. Overall, our results are consistent with insect ferritin combining three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress. These functions are required in multiple tissues during Drosophila embryonic development.
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