SynthesisPloS one2015
Impact of Inhaled Corticosteroids on Growth in Children with Asthma: Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of long-term inhaled corticosteroids on growth velocity and adult height in children with asthma: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The impact of identifying laryngeal obstruction syndromes on reducing treatment of pediatric asthma: A systematic review.Pediatric pulmonology · 2022Pooled it
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- A systematic review of adverse drug events associated with administration of common asthma medications in children.PloS one · 2017Pooled it
- Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatric asthma patients: a randomized controlled trial.Therapeutic advances in respiratory diseaseTrial
- Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial.EClinicalMedicine · 2026Article
- Corticosteroid-Induced neuropsychiatric manifestations: From pathophysiology to management.Psychopharmacology · 2026Review
- Clinical Outcomes Associated With Long-Acting Beta Agonist Escalation in Preschool Children With Severe Asthma: A Retrospective Hospital Based Clinic Cohort Study.Pediatric pulmonology · 2026Observational
- Association between combined allergic rhinitis and asthma syndrome in children and nitric oxide: mechanisms, clinical significance, and research progress.Frontiers in immunology · 2026Review
- Potential Determinants of Progression from Cough-Variant Asthma to Classic Asthma in Children: Evidence, Mechanisms, and Clinical Research Gaps.Journal of asthma and allergy · 2026Review
- Poor growth in multi-ethnic children with food allergy in Amsterdam.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Optimizing Pediatric Asthma Management: Implementation and Evaluation of Anti-Inflammatory Reliever and Single Maintenance and Reliever Therapies.The journal of allergy and clinical immunology. In practice · 2025Review
- Unveiling the Complexities of Pediatric Asthma Treatment: Evidence, Controversies, and Emerging Approaches.Paediatric drugs · 2025Review
- Preschool Asthma Children: Navigating COVID-19's Impact on Treatment Adherence.Turkish archives of pediatrics · 2025Article
- Short Course of Systemic Steroids for Acute Respiratory Diseases During Infancy and Final Adult Height, Weight, and BMI: Preliminary Results from a Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Systemic Adverse Events Associated with Locally Administered Corticosteroids.Children (Basel, Switzerland) · 2024Article
- Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024Review
- Medical resource utilization and the associated costs of asthma in China: a 1-year retrospective study.BMC pulmonary medicine · 2023Article
- Adverse Drug Events Related to Common Asthma Medications in US Hospitalized Children, 2000-2016.Drugs - real world outcomes · 2022Article
- Relationship between maternal folic acid supplementation during pregnancy and risk of childhood asthma: Systematic review and dose-response meta-analysis.Frontiers in pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term inhaled corticosteroids (ICS) may reduce growth velocity and final height of children with asthma. We aimed to evaluate the association between ICS use of >12 months and growth.
methodsWe initially searched MEDLINE and EMBASE in July 2013, followed by a PubMed search updated to December 2014. We selected RCTs and controlled observational studies of ICS use in patients with asthma. We conducted random effects meta-analysis of mean differences in growth velocity (cm/year) or final height (cm) between groups. Heterogeneity was assessed using the I2 statistic.
resultsWe found 23 relevant studies (twenty RCTs and three observational studies) after screening 1882 hits. Meta-analysis of 16 RCTs showed that ICS use significantly reduced growth velocity at one year follow-up (mean difference -0.48 cm/year (95% CI -0.66 to -0.29)). There was evidence of a dose-response effect in three RCTs. Final adult height showed a mean reduction of -1.20 cm (95% CI -1.90 cm to -0.50 cm) with budesonide versus placebo in a high quality RCT. Meta-analysis of two lower quality observational studies revealed uncertainty in the association between ICS use and final adult height, pooled mean difference -0.85 cm (95% CI -3.35 to 1.65).
conclusionUse of ICS for >12 months in children with asthma has a limited impact on annual growth velocity. In ICS users, there is a slight reduction of about a centimeter in final adult height, which when interpreted in the context of average adult height in England (175 cm for men and 161 cm for women), represents a 0.7% reduction compared to non-ICS users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.