ArticleJournal of clinical hypertension (Greenwich, Conn.)2015
Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Central blood pressure for the management of hypertension: Is it a practical clinical tool in current practice?Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Quality-of-care of Filipino patients with hypertension in primary care settings.BMC primary care · 2026Article
- Antihypertensive Prescribing for Uncomplicated, Incident Hypertension: Opportunities for Cost Savings.CJC open · 2021Article
- Comparison of 24-Hour Ambulatory Central Blood Pressure Reduction Efficacy Between Fixed Amlodipine or Up-Titrated Hydrochlorothiazide Plus Losartan: The K-Central Study.American journal of hypertension · 2019Article
- Comparative effectiveness of antihypertensive drugs in nondiabetic patients with hypertension: A population-based study.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Hydrochlorothiazide--Teaching an Old Drug New Tricks.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Thiazide diuretics (TDs) are a cost-effective first-line therapy for uncomplicated hypertension; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic hypertensive participants on monotherapy for hypertension were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 hypertensive participants, 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated hypertension.
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