Evidence map›Paper›PMID 26191606›Full record

ArticleBioconjugate chemistry2015

Bile Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic Anhydrase-II in the Presence of MicroRNA-21.

Xiaozhu Chu, Cooper H Battle, Nan Zhang, Gyan H Aryal, Madhusoodanan Mottamal, Janarthanan Jayawickramarajah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. DNA Strand Displacement Driven by Host-Guest Interactions.Journal of the American Chemical Society · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaozhu Chu†Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana 70118, United States.
Cooper H Battle†Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana 70118, United States.
Nan Zhang†Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana 70118, United States.
Gyan H Aryal†Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana 70118, United States.
Madhusoodanan Mottamal‡RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, Louisiana 70125, United States.
Janarthanan Jayawickramarajah†Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, Louisiana 70118, United States.
Tulane University · USXavier University of Louisiana · US

Funding

Xavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7M
Supramolecular Approaches to Protein Inhibitors Activated by MicroRNA-21R01GM097571 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI JAYAWICKRAMARAJAH, JANARTHANAN · 2012 to 2016
$1.4M
NIGMS NIH HHS R01 GM097571NIGMS NIH HHS R01GM097571NIMHD NIH HHS 2G12MD007595NIMHD NIH HHS G12 MD007595
6 · The paper itself

Abstract

In order to tackle the issue of systemic toxicity in chemotherapy, there is a need to develop novel mechanisms for the activation of protein inhibitors using biomarkers overexpressed in cancer cells. Many current strategies focus on using cancer associated enzymes as a triggering agent for prodrugs. Herein, we detail an alternative approach that harnesses a microRNA (miR-21) that is overexpressed in cancers as the trigger that activates an inhibitor of human carbonic anhydrase-II (hCA-II). Specifically, we have developed a DNA-small molecule chimera (DC) composed of an hCA-II binding lithocholic acid amide (LAA) headgroup that can transition from a rigid duplex state (that does not bind appreciably to hCA) to a single-stranded conformation via a miR-21 trigger. The activated single-stranded DC can project the LAA headgroup into the hCA-II active site and is a robust hCA-II inhibitor (K(i) of 3.12 μM). This work may spur research into developing new classes of cancer selective protein inhibitors.

Indexed as

Bile Acids and SaltsCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCatalytic DomainDNAHumansMicroRNAsModels, MolecularStructure-Activity RelationshipBile Acids and SaltsCarbonic Anhydrase IICarbonic Anhydrase InhibitorsDNAMicroRNAsMIRN21 microRNA, human

Identifiers

PMID26191606
PMCPMC4709253
OpenAlexW1002918421

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.