ArticleAnnals of pediatric endocrinology & metabolism2015
Elevation of serum creatine kinase during methimazole treatment of Graves disease in a 13-year-old girl and a literature review of similar cases.
Article in Annals of pediatric endocrinology & metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- [Methimazole Tablets-Induced Algospasm: Two Cases Report].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- Myopathy Associated with Treatment of Graves' Disease.Medicina (Kaunas, Lithuania) · 2021Article
- Cross-sectional investigation of serum creatine kinase concentration in Graves disease patients treated with oral antithyroid drugs.Medicine · 2020Article
- Myopathy after rapid correction of hyperthyroidism: A case report and review of literature.Medicine · 2020Review
- Erratic movement disorders disclosing Graves' disease and paralleling thyroid function but not autoantibody levels.The Journal of international medical research · 2019Article
- Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report.Medicine · 2017Article
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5 authors at 2 institutions in 1 country.
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Abstract
We report a 13-year-old girl with Graves disease, who showed an increased level of serum creatine kinase (CK) accompanied by myalgia after methimazole (MMI) treatment. This patient developed muscular pain two weeks after MMI administration, along with increased CK levels. The level of thyroid hormone was within the normal range when she showed increased CK levels. After the MMI dose was decreased and levo-thyroxine was added, serum CK levels decreased to normal and the myalgia improved. The pathophysiologic mechanism of this effect has not yet been elucidated. An acute relatively hypothyroid state occurs secondary to antithyroid drug (ATD) administration in chronic hyperthyroidism, which may cause changes in the CK levels. In this report, we present a rare pediatric case, along with a literature review of similar cases. In the initial state of MMI treatment, myalgia should be detected and when it occurs, CK levels should be measured. The clinical strategy of monitoring CK levels with the aim of normalizing thyroid hormones is helpful in case of the development of adverse reactions, such as myalgia, during ATD treatment for Graves disease in children.
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