Evidence map›Paper›PMID 26191352›Full record

ArticleWorld journal of gastrointestinal oncology2015

Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer.

Devulapalli Krishnaveni, Bhayal Amar Chand, Porika Shravan Kumar, Malladi Uma Devi, Macherla Ramanna, Akka Jyothy, Nallari Pratibha, N Balakrishna, Ananthapur Venkateshwari

Open access · hybridAbstract read
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Article in World journal of gastrointestinal oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  5. The genetic association betweenOncoTargets and therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Devulapalli KrishnaveniDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Bhayal Amar ChandDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Porika Shravan KumarDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Malladi Uma DeviDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Macherla RamannaDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Akka JyothyDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Nallari PratibhaDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
N BalakrishnaDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Ananthapur VenkateshwariDevulapalli Krishnaveni, Bhayal Amar Chand, Akka Jyothy, Ananthapur Venkateshwari, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Telangana, India.
Institute of Genetics and Hospital for Genetic Diseases · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the role of endothelial nitric oxide synthase -786T > C promoter polymorphism in the etiology of gastric cancer (GC).

methodsA total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori (H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software.

resultsThere was a significant difference in the distribution of C allele (C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype (T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects (P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition (smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity (P = 0.473).

conclusionThe Present data suggest that eNOS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC.

Indexed as

Agarose gel electrophoresisAllele specific polymerase chain reactionEndoscopyGastro duodenalGeneticsHelicobacter pyloriNitric oxideNutritionOncologySingle nucleotide polymorphism rs2070744

Identifiers

PMID26191352
PMCPMC4501928
OpenAlexW996470125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.