Evidence map›Paper›PMID 26191336›Full record

ArticleStatistics and its interface

Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions.

Iryna Lobach, Ruzong Fan, Prashiela Manga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Statistics and its interface. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iryna LobachDepartment of Neurology, School of Medicine, University of California, San Francisco, CA 94185, USA.
Ruzong FanBiostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA.
Prashiela MangaRonald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, NY 10016, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
FAMILY STUDY OF COCAINE DEPENDENCER01DA013423 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA JEAN · 2000 to 2004
$2.2M
Study of Addiction: Genetics and EnvironmentU01HG004422 · NHGRI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2007 to 2010
$1.2M
Statistical Methods for Association Analysis of Complex TraitsZIAHD008918 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI FAN, RUZONG · 2011 to 2016
$1.1M
Novel Analysis of Gene-Gene and Gene-Environment Interactions in AlcoholismR21AA020356 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOBACH, IRYNA · 2013 to 2014
$407k
Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD008918NCI NIH HHS P01 CA089392NCI NIH HHS P30 CA016087NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS R21 AA020356NIAAA NIH HHS U10 AA008401NIDA NIH HHS R01 DA013423
6 · The paper itself

Abstract

A central problem in genetic epidemiology is to identify and rank genetic markers involved in a disease. Complex diseases, such as cancer, hypertension, diabetes, are thought to be caused by an interaction of a panel of genetic factors, that can be identified by markers, which modulate environmental factors. Moreover, the effect of each genetic marker may be small. Hence, the association signal may be missed unless a large sample is considered, or

Identifiers

PMID26191336
PMCPMC4504431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.