Evidence map›Paper›PMID 26191281›Full record

ArticleInternational journal of clinical and experimental pathology2015

No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.

Ping Zhou, Shuo Zhang, Hongyan Chen, Yuanyuan Chen, Xiaodong Liu, Bing Sun

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ping ZhouDepartment of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital, Fudan University Shanghai, China.
Shuo ZhangState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University Shanghai, PR China.
Hongyan ChenState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University Shanghai, PR China.
Yuanyuan ChenState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University Shanghai, PR China.
Xiaodong LiuDepartment of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital, Fudan University Shanghai, China.
Bing SunDepartment of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital, Fudan University Shanghai, China.
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vesicle-associated membrane protein 8 (VAMP8) gene plays an important role in biological functions like endosomal fusion, sequential granule-to-granule fusion and autophagy. The current research identified VAMP8 acted as a novel oncogene by promoting cell proliferation and therapeutic resistance in glioma. Nevertheless, the association between VAMP8 genes polymorphism and glioma patients has not been well studied. In our study, to explore the association between single nucleotide polymorphisms (SNPs) of VAMP8 gene with glioma risk in the Chinese Han population, we performed a hospital based case-control study (992 cases and 1008 controls). Eight common tagging SNPs of VAMP8 gene were genotyped, while no significant difference in allele or genotype frequency was found between glioma patients and healthy controls. No positive linkage disequilibrium (LD) was detected either. No haplotype distribution was positive. Accordingly, our study suggested that VAMP8 gene variants might not contribute to glioma susceptibility and associated with glioma in the Chinese Han population.

Indexed as

AdultAsian PeopleBrain NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeGliomaHumansMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideR-SNARE ProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationR-SNARE ProteinsVAMP8 protein, humangenetic susceptibilitygliomamolecular biologypolymorphismsVAMP8 gene

Identifiers

PMID26191281
PMCPMC4503152
OpenAlexW2404447925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.