Evidence map›Paper›PMID 26191278›Full record

ArticleInternational journal of clinical and experimental pathology2015

Evaluation of correlation of articular cartilage staining for DDR2 and proteoglycans with histological tissue damage and the results of radiographic assessment in patients with early stages of knee osteoarthritis.

Siim Suutre, Irina Kerna, Mare Lintrop, Hannes Tamm, Marina Aunapuu, Andres Arend, Agu Tamm

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In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Siim SuutreDepartment of Anatomy, University of Tartu Estonia.
Irina KernaInternal Medicine Clinic, Tartu University Hospital Estonia.
Mare LintropRadiology Clinic, Tartu University Hospital Estonia.
Hannes TammPathology Service, Tartu University Hospital Estonia.
Marina AunapuuDepartment of Anatomy, University of Tartu Estonia.
Andres ArendDepartment of Anatomy, University of Tartu Estonia.
Agu TammInternal Medicine Clinic, Tartu University Hospital Estonia.
University of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine, if staining of articular cartilage for proteoglycans (natural element of healthy and functioning cartilage) and discoidin domain receptor 2 (DDR2) (a protein associated with articular cartilage degradation) is correlated with histological tissue damage or radiographic assessment score in patients with early stages of knee osteoarthritis (OA).

method40 patients, with early stage OA were enrolled, from whom the biopsies for histological and immunohistochemical studies were obtained from edge of the femoral condyle during the arthroscopy. Semi-quantitative computer based analysis was used to evaluate the proportion of staining in histological sections.

resultsNo correlation was shown between the proportion of tissue stained for DDR2 and histological score or the results of radiographic assessment of tibiofemoral (TF) joint. There was a negative correlation between the proportion of tissue stained for DDR2 and radiographic grade of patellofemoral (PF) OA (Spearman r=-0.34; 95% CI -0.60 to -0.02; P=0.03). No correlation was shown between the proportion of tissue stained for proteoglycans and histological score or the results of radiographic assessment of TF and PF joints. A negative correlation was found between proportion of tissue stained for DDR2 and proteoglycans. Spearman r=-0.43; 95% CI=-0.66 to -0.12; P=0.006.

conclusionProduction of DDR2 in articular cartilage could be related to early stages of OA, as it is significantly correlated to decrease of staining for cartilage proteoglycans. The role of production of DDR2 in cartilage may be decreased in stages, where higher grades of OA are detected on the radiographs.

Indexed as

ImmunohistochemistryAdultArthroscopyBiomarkersBiopsyCartilage, ArticularDiscoidin Domain ReceptorsFemaleHumansKnee JointMaleMiddle AgedOsteoarthritis, KneePredictive Value of TestsPrognosisProteoglycansBiomarkersDiscoidin Domain ReceptorsProteoglycansReceptor Protein-Tyrosine KinasesReceptors, MitogenDDR2Osteoarthritisproteoglycanstissue damage

Identifiers

PMID26191278
PMCPMC4503149
OpenAlexW2416230523

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.