ArticleInternational journal of clinical and experimental pathology2015
Is tumor length a prognostic indicator for esophageal squamous cell carcinoma? A single larger study among Chinese patients.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic impact of tumor length in esophageal Cancer: a systematic review and Meta-analysis.BMC cancer · 2021Pooled it
- Pooled it
- Predictors of Understaging with EUS and PET-CECT in Early Esophageal Carcinoma.Journal of gastrointestinal cancer · 2024Article
- A computed tomography-based nomogram for neoadjuvant chemotherapy plus immunotherapy response prediction in patients with advanced esophageal squamous cell carcinoma.Frontiers in oncology · 2024Article
- Impact of adjuvant chemotherapy for radically resected esophageal squamous cell carcinoma: a propensity score matching analysis.Frontiers in surgery · 2023Article
- Development and validation of a nomogram prognostic model for esophageal cancer patients with oligometastases.Scientific reports · 2020Article
- Tumour length as an independent prognostic factor in resectable oesophageal carcinoma.Annals of the Royal College of Surgeons of England · 2020Article
- Tumor Size as a Critical Prognostic Factor in T1-2 Stage Esophageal Cancer.Gastroenterology research and practice · 2020Article
- The long-term impact of tumor burden in pT3N0M0 esophageal squamous cell carcinoma: A propensity score-matched analysis.Medicine · 2019Article
- Survival based radiographic-grouping for esophageal squamous cell carcinoma may impact clinical T stage.Oncotarget · 2018Article
- Article
- Postoperative radiation therapy of pT2-3N0M0 esophageal carcinoma-a review.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
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Authors and funding
9 authors.
Funding
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Abstract
objectiveIn esophageal cancer, depth of wall penetration, reflected by T classification, represents the most important prognostic variable. Our study aimed to investigate the impact of tumor length, measured as the longitudinal length, on the outcome of esophageal squamous cell carcinoma (ESCC) patients.
methodsThe survival data of 362 ESCC patients who underwent surgical resection as the primary treatment between 1999 and 2007 were collected retrospectively. Receiver-operator characteristic analysis was applied to identify the optimal cut-off values.
results4.0 cm was identified as the optimal cut-off value within the whole group. Tumor length greater than 4.0 cm was associated with increasing T stage (P=0.001), N stage (P=0.046), and tumor differentiation (P=0.033). Univariate analysis and multivariate analysis both found that tumor length greater than 4.0 cm was associated with worse overall survival compared with shorter tumors (P<0.001). It appeared to have a greater impact on N0-N1 (P<0.001, P=0.026, respectively) than N2-N3 and appeared to have a higher impact on the lower-stage patients than the higher-stage patients.
conclusionsTumor length proved to be an independent prognostic parameter for ESCC patients, especially for node-negative and lower-stage patients. More attention should be paid to its role in the management of ESCC.
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