ArticleInternational journal of clinical and experimental pathology2015
Expression of the μ, κ, and δ-opioid receptors and tyrosine hydroxylase in MN9D cells.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
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- Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease.PloS one · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopaminergic neurons are suggested to be a critical physiopathology substrate for addiction disorders. It is not well known whether the clonal mesencephalic dopaminergic cell line MN9D cells can be applied to study morphine addiction. Immunofluorescence staining and reverse transcription-polymerase chain reaction (RT-PCR) were used to detect protein and mRNA expression of the μ, κ, and δ-opioid receptors in MN9D cells. Immunofluorescence staining of TH was applied to quantify the number of dopaminergic neurons. The results showed that the μ, κ, and δ-receptors were all expressed in MN9D cells, and the number of TH-positive cells was significantly greater in the MN9D cells than SH-SY5Y cells. The data suggest that MN9D cells can be used as an in vitro models in future studies to explore the mechanisms of morphine addiction related to dopaminergic neurons.
Indexed as
Identifiers
26191179PMC4503051W988240871What OpenQuestion holds
Registered trials
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