ArticleInternational journal of clinical and experimental pathology2015
Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFκB activation.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Boric acid-functionalized bentonite nanostructures attenuated paraquat-induced pulmonary injuries in rats.Scientific reports · 2025Article
- Azilsartan attenuates lipopolysaccharide-induced acute lung injury via the Nrf2/HO-1 signaling pathway.Immunologic research · 2022Article
- Ramelteon Ameliorates LPS-Induced Hyperpermeability of the Blood-Brain Barrier (BBB) by Activating Nrf2.Inflammation · 2021Article
- Protective Activity of Aspirin Eugenol Ester on Paraquat-Induced Cell Damage in SH-SY5Y Cells.Oxidative medicine and cellular longevity · 2021Article
- Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics.Scientific reports · 2020Article
- Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics.Scientific reports · 2020Article
- Rapamycin attenuates the paraquat-induced pulmonary fibrosis through activating Nrf2 pathway.Journal of cellular physiology · 2020Article
- The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats.Frontiers in medicine · 2020Article
- Neutrophil-lymphocyte ratio as an early predictor for patients with acute paraquat poisoning: A retrospective analysis.Medicine · 2019Article
- The successful treatment of systemic toxic induced paraquat poisoning by skin absorption: case reports and a literature review.International journal of clinical and experimental pathology · 2019Article
- The Role of Autophagy and the Chemokine (C-X-C Motif) Ligand 16 During Acute Lung Injury in Mice.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.Inflammation · 2017Article
- Effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury.Biomedical reports · 2017Article
- Paraquat disrupts the anti-inflammatory action of cortisol in human macrophagesToxicology research · 2017Article
- Role of Nrf2 and Autophagy in Acute Lung Injury.Current pharmacology reports · 2016Article
- Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the role of rapamycin (RAPA) in paraquat (PQ)-induced acute lung injury.
methodsLung tissues were stained with HE and lung histology was observed. Mortality rate, and neutrophil and leukocyte count in blood and bronchoalveolar lavage fluid (BALF) were recorded. Protein content in BALF was determined by Coomassie blue staining. Malondialdehyde (MDA) content, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activity in blood were determined by thiobarbituric acid (TBA) assay, pyrogallol autoxidation method, and modified Haefman method, respectively. The NF-κB activity was measured by gel electrophoretic mobility shift assay (EMSA). Carbon dioxide partial pressure (PaCO2), partial pressure of oxygen (PaO2) and pH values were measured by automated blood gas analyzer.
resultsHE staining results demonstrated RAPA alleviated pathological changes of acute alveolitis in SD rats. Trend of protein content in BALF was PQ group>RAPA treatment group>control group (P<0.05). Neutrophil and leukocyte count in RAPA treatment group was significantly lower than PQ group at 3, 5, and 7 days after injection (P<0.05). Trend of MDA content was RAPA treatment group>PQ group>control group (P<0.05). Trend of GSH-Px and SOD activity was control group>RAPA treatment group>PQ group (P<0.05). Compared with PQ group, PaO2 in RAPA treatment group was markedly higher and PaCO2 was lower (P<0.05).
conclusionPQ-induced acute lung injury was effectively reversed with RAPA, through inhibition of NF-κB activation.
Indexed as
Identifiers
26191153PMC4503025W2414746581What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.