ArticleInternational journal of clinical and experimental pathology2015
MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Role ofCancers · 2025Review
- miR-128-3p suppresses tumor growth and enhances chemosensitivity in tongue squamous cell carcinoma through MAP2K7 targeting.Molecular biology reports · 2024Article
- Review
- MicroRNAs as Modulators of Oral Tumorigenesis-A Focused Review.International journal of molecular sciences · 2021Review
- Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer.BMC medical genomics · 2020Article
- Pichia fermentans originates apoptosis in human oral squamous cell carcinoma by over-expressing BAX and CASP 9 genes.Cytotechnology · 2020Article
- Article
- Inferring novel genes related to oral cancer with a network embedding method and one-class learning algorithms.Gene therapy · 2019Article
- Exosomes derived from microRNA-101-3p-overexpressing human bone marrow mesenchymal stem cells suppress oral cancer cell proliferation, invasion, and migration.Molecular and cellular biochemistry · 2019Article
- miR‑148a modulates the viability, migration and invasion of oral squamous cell carcinoma cells by regulating HLA‑G expression.Molecular medicine reports · 2019Article
- MicroRNAs as effective surrogate biomarkers for early diagnosis of oral cancer.Clinical oral investigations · 2018Review
- MicroRNA-300 suppresses metastasis of oral squamous cell carcinoma by inhibiting epithelial-to-mesenchymal transition.OncoTargets and therapy · 2018Article
- MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.BioMed research international · 2018Article
- Molecular pathways of oral cancer that predict prognosis and survival: A systematic review.Journal of carcinogenesis · 2018Review
- MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.Oncology letters · 2017Article
- miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14.BioMed research international · 2017Article
- Detection of survivin, carcinoembryonic antigen and ErbB2 level in oral squamous cell carcinoma patients.Cancer biomarkers : section A of Disease markers · 2016Article
- Effects of microRNA-139 on myocardial cell injury induced by oxidative stress.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral cancer threats people's life and health seriously. Traditional treatment (surgery, radiotherapy, chemotherapy and traditional Chinese medicine treatment) is lack of pertinence that affects curative effect and prognosis. Therefore, it is necessary to explore the specific targets for oral cancer treatment. MiRNA-139 was transfected into oral cancer Tca8113 cells. Methyl thiazolyl tetrazolium (MTT) was applied to test cell proliferation. Flow cytometry was used to detect oral cancer Tca8113 cells apoptosis. miR-139 significantly inhibits oral cancer Tca8113 cells proliferation and induces cell apoptosis. SH-5 obviously weakened the cell apoptosis caused by miR-139. miR-139 could induce Tca8113 cell apoptosis through Akt signaling pathway. It may develop a more effective method for oral cancer treatment by this target.
Indexed as
Identifiers
26191149PMC4503021What OpenQuestion holds
Registered trials
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