ArticleStatistics in biosciences2015
Bayesian Hierarchical Model for Differential Gene Expression Using RNA-seq Data.
Article in Statistics in biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
We introduce model-based Bayesian inference to screen for differentially expressed genes based on RNA-seq data. RNA-seq is a high-throughput next-generation sequencing application that can be used to measure the expression of messenger RNA. We propose a Bayesian hierarchical model to implement coherent, fast and robust inference, focusing on differential gene expression experiments, i.e., experiments carried out to learn about differences in gene expression under two biologic conditions. The proposed model exploits available position-specific read counts, minimizing required data pre-processing and making maximum use of available information. Moreover, it includes mechanisms to automatically discount outliers at the level of positions within genes. The method combines gene-level information across replicates, and reports coherent posterior probabilities of differential expression at the gene level. An implementation as a public domain R package is available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.