ReviewFrontiers in immunology2015
iNKT and MAIT Cell Alterations in Diabetes.
Review in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Intestinal mucosal immunity and type 1 diabetes: Non-negligible communication between gut and pancreas.Diabetes, obesity & metabolism · 2025Review
- Changes in circulating NK and innate-like T cells in type 1 and type 2 diabetes.Frontiers in immunology · 2025Article
- Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration.Journal of inflammation research · 2025Article
- Protective effects ofFrontiers in pharmacology · 2024Article
- Dysfunction of circulating CD3International journal of medical sciences · 2023Article
- Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022Article
- Involvement of impaired CD8Reproductive biology and endocrinology : RB&E · 2021Article
- Impact of Bariatric Surgery on Adipose Tissue Biology.Journal of clinical medicine · 2021Review
- Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women.Sports (Basel, Switzerland) · 2021Article
- Does exercise attenuate age- and disease-associated dysfunction in unconventional T cells? Shining a light on overlooked cells in exercise immunology.European journal of applied physiology · 2021Review
- Sex discrepancy in the reduction of mucosal-associated invariant T cells caused by obesity.Immunity, inflammation and disease · 2021Article
- Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy.Folia microbiologica · 2020Article
- The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging.Frontiers in endocrinology · 2020Review
- Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease.Frontiers in immunology · 2020Article
- CD4Reproductive biology and endocrinology : RB&E · 2019Article
- Mucosal-associated invariant T cells and disease.Nature reviews. Immunology · 2019Review
- The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity.Frontiers in immunology · 2019Review
- Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes.Frontiers in immunology · 2019Review
- Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.JCI insight · 2018Article
- Innate Lymphocytes in Adipose Tissue Homeostasis and Their Alterations in Obesity and Colorectal Cancer.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in T2D and obese patients. Regarding iNKT cells many studies in non-obese diabetic mice demonstrated their protective role against T1D whereas their potential role in human T1D is still under debate. Studies in mouse models and patients suggest that iNKT cells present in adipose tissue (AT) could exert a regulatory role against obesity and associated metabolic disorders, such as T2D. Scarce data are yet available on MAIT cells; however, we recently described MAIT cell abnormalities in the blood and ATs from obese and T2D patients. These data show that a link between MAIT cells and metabolic disorders pave the way for further investigations on MAIT cells in T1D and T2D in humans and mouse models. Furthermore, we hypothesize that the gut microbiota alterations associated with T1D and T2D could modulate iNKT and MAIT cell frequency and functions. The potential role of iNKT and MAIT cells in the regulation of metabolic pathways and their cross-talk with microbiota represent exciting new lines of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.