ArticleFrontiers in microbiology2015
The AirSR two-component system contributes to Staphylococcus aureus survival in human blood and transcriptionally regulates sspABC operon.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Palladium(II) Metal Complex Fabricated Titanium Implant Mitigates Dual-Species Biofilms in Artificial Synovial Fluid.Antibiotics (Basel, Switzerland) · 2023Article
- Targeting multidrug resistantChemical science · 2023Article
- Regulation ofPharmaceutics · 2023Review
- Two-Component Systems ofGenes · 2021Review
- Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia.Pathogens (Basel, Switzerland) · 2021Article
- Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR.Nucleic acids research · 2019Article
- Control ofInfection and immunity · 2019Article
- Functional analysis of the EsaB component of theMicrobiology (Reading, England) · 2017Article
- The RicAFT (YmcA-YlbF-YaaT) complex carries two [4Fe-4S]Molecular microbiology · 2017Article
- The Staphylococcus aureus AirSR Two-Component System Mediates Reactive Oxygen Species Resistance via Transcriptional Regulation of Staphyloxanthin Production.Infection and immunity · 2017Article
- The SaeRS Two-Component System Controls Survival ofFrontiers in cellular and infection microbiology · 2017Article
- Staphylococcus aureus pathogenesis in diverse host environments.Pathogens and disease · 2017Review
- Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster.The Journal of biological chemistry · 2016Article
- Cinnamaldehyde InhibitsFrontiers in microbiology · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To date, genes identified and transcriptionally regulated by the AirSR TCS have been involved in energy production and cellular homeostasis of the staphylococcal cell. It is well accepted that the state of cellular metabolism impacts the expression of virulence factors in Staphylococcus aureus. For this reason, we conducted experiments to determine if the AirSR TCS contributes to the pathogenesis of S. aureus using an antisense RNA interference technology, an inducible overexpression system, and gene deletions. Depletion of AirSR by antisense RNA expression or deletion of the genes, results in significant decrease in bacterial survival in human blood. Conversely, overexpression of AirR significantly promotes survival of S. aureus in blood. AirR promotes the secretion of virulence factors that inhibits opsonin-based phagocytosis. This enhanced survival is partially linked to the transcriptional regulation of the sspABC operon, encoding V8 protease (SspA), staphopain B (SspB) and staphostatin B (SspC). SspA and SspB are known virulence factors which proteolytically digest opsonins and inhibit killing of S. aureus by professional phagocytes. This is the first evidence linking the AirSR TCS to pathogenesis of S. aureus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.