Evidence map›Paper›PMID 26191000›Full record

ArticleFrontiers in aging neuroscience2015

Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia.

Rachel H Tan, Emma Devenney, Matthew C Kiernan, Glenda M Halliday, John R Hodges, Michael Hornberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rachel H TanAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.
Emma DevenneyAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.
Matthew C KiernanAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; Sydney Medical School, Brain and Mind Research Institute, University of Sydney Sydney, NSW, Australia.
Glenda M HallidayAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.
John R HodgesAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia ; Australian Research Council Centre of Excellence in Cognition and Its Disorders Sydney, NSW, Australia.
Michael HornbergerAgeing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; Department of Clinical Neurosciences, Cambridge University Cambridge, UK.
Neuroscience Research Australia · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

Indexed as

behavioral variant frontotemporal dementiacerebellumcognitionneural correlatesneuropsychiatric processes

Identifiers

PMID26191000
PMCPMC4488961
OpenAlexW1570777051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.