ArticleFrontiers in behavioral neuroscience2015
Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Lateral hypothalamic melanin-concentrating hormone neuron dynamics in rats during sensory stimulation and sugar sweetened alcoholic cocktail drinking.bioRxiv : the preprint server for biology · 2026Article
- Article
- Free-choice high-fat diet consumption reduces lateral hypothalamic GABAergic activity, without disturbing neural response to sucrose drinking in mice.Frontiers in neuroscience · 2023Article
- Contrasting dose-dependent effects of acute intravenous methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats.Journal of neurophysiology · 2022Article
- Rapid fluctuations in brain oxygenation during glucose-drinking behavior in trained rats.Journal of neurophysiology · 2022Article
- Effects of alcohol on brain oxygenation and brain hypoxia induced by intravenous heroin.Neuropharmacology · 2021Article
- The Sugars in Alcohol Cocktails Matter.ACS chemical neuroscience · 2021Article
- Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl.Neuropharmacology · 2019Review
- Brain temperature and its role in physiology and pathophysiology: Lessons from 20 years of thermorecording.Temperature (Austin, Tex.) · 2019Review
- Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone.Neuropharmacology · 2018Article
- Central and Peripheral Mechanisms Underlying Physiological and Drug-Induced Fluctuations in Brain Oxygen in Freely-Moving Rats.Frontiers in integrative neuroscience · 2018Review
- Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation.ACS chemical neuroscience · 2017Article
- Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation.Frontiers in integrative neuroscience · 2017Article
- MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice.Physiology & behavior · 2016Article
- Brain glucose feedback predicts food choice (Commentary on Wakabayashi et al.).The European journal of neuroscience · 2016Article
- Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain.The European journal of neuroscience · 2016Article
- Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation.Frontiers in physiology · 2016Article
- Methylenedioxypyrovalerone (MDPV) mimics cocaine in its physiological and behavioral effects but induces distinct changes in NAc glucose.Frontiers in neuroscience · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Glucose is the primary energetic substrate for the metabolic activity of brain cells and its proper delivery from the arterial blood is essential for neural activity and normal brain functions. Glucose is also a unique natural reinforcer, supporting glucose-drinking behavior without food or water deprivation. While it is known that glucose enters brain tissue via gradient-dependent facilitated diffusion, it remains unclear how glucose levels are changed during natural behavior and whether the direct central action of ingested glucose can be involved in regulating glucose-drinking behavior. Here, we used glucose biosensors with high-speed amperometry to examine the pattern of phasic and tonic changes in extracellular glucose in the nucleus accumbens (NAc) during unrestricted glucose-drinking in well-trained rats. We found that the drinking behavior is highly cyclic and is associated with relatively large and prolonged increases in extracellular glucose levels. These increases had two distinct components: a highly phasic but relatively small behavior-related rise and a larger tonic elevation that results from the arrival of consumed glucose into the brain's extracellular space. The large post-ingestion increases in NAc glucose began minutes after the cessation of drinking and were consistently associated with periods of non-drinking, suggesting that the central action of ingested glucose could inhibit drinking behavior by inducing a pause in activity between repeated drinking bouts. Finally, the difference in NAc glucose responses found between active, behavior-mediated and passive glucose delivery via an intra-gastric catheter confirms that motivated behavior is also associated with metabolic glucose use by brain cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.