ArticleFrontiers in cellular neuroscience2015
The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Regulation of Metabolic Rhythms by Glial Clocks.Journal of biological rhythms · 2026Article
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit.Neuron · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells.Biology open · 2022Article
- Glia-Neurons Cross-Talk Regulated Through Autophagy.Frontiers in physiology · 2022Article
- Post-transcriptional modulators and mediators of the circadian clock.Chronobiology international · 2021Review
- Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation.Addiction biology · 2021Article
- The Glial Perspective on Sleep and Circadian Rhythms.Annual review of neuroscience · 2020Review
- Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.The European journal of neuroscience · 2020Review
- Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity.Current opinion in neurobiology · 2019Review
- Alcohol sedation in adultCommunications biology · 2019Article
- The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation inFrontiers in physiology · 2019Article
- Endocytosis at theeLife · 2018Article
- Regulation of Circadian Behavior by Astroglial MicroRNAs inGenetics · 2018Article
- On Variations in the Level of PER in Glial Clocks ofFrontiers in physiology · 2018Article
- Different Levels of Expression of the Clock Protein PER and the Glial Marker REPO in Ensheathing and Astrocyte-Like Glia of the Distal Medulla ofFrontiers in physiology · 2018Article
- Glial contributions to neuronal health and disease: new insights from Drosophila.Current opinion in neurobiology · 2017Review
- Neuronal and Glial Clocks Underlying Structural Remodeling of Pacemaker Neurons inFrontiers in physiology · 2017Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
We previously showed that endocytosis and/or vesicle recycling mechanisms are essential in adult Drosophila glial cells for the neuronal control of circadian locomotor activity. In this study, our goal was to identify specific glial vesicle trafficking, recycling, or release factors that are required for rhythmic behavior. From a glia-specific, RNAi-based genetic screen, we identified eight glial factors that are required for normally robust circadian rhythms in either a light-dark cycle or in constant dark conditions. In particular, we show that conditional knockdown of the ROP vesicle release factor in adult glial cells results in arrhythmic behavior. Immunostaining for ROP reveals reduced protein in glial cell processes and an accumulation of the Par Domain Protein 1ε (PDP1ε) clock output protein in the small lateral clock neurons. These results suggest that glia modulate rhythmic circadian behavior by secretion of factors that act on clock neurons to regulate a clock output factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.