ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C.
Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Divergent Synthesis of ΔAA-Peptides Using a Bioorthogonal pro-Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity.Angewandte Chemie (International ed. in English) · 2025Article
- Insight into the structure of antitubercular Callyaerins: conformational studies and synthesis of a unique dehydroamino acid, β-aminodehydroalanine.Amino acids · 2025Article
- Insight into the Structure of Victorin, the Host-Selective Toxin from the Oat PathogenJournal of agricultural and food chemistry · 2023Article
- Synthesis of Tetrapeptides Containing Dehydroalanine, Dehydrophenylalanine and Oxazole as Building Blocks for Construction of Foldamers and Bioinspired Catalysts.Molecules (Basel, Switzerland) · 2022Article
- Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel.Nanomaterials (Basel, Switzerland) · 2021Article
- Dehydropeptide Supramolecular Hydrogels and Nanostructures as Potential Peptidomimetic Biomedical Materials.International journal of molecular sciences · 2021Review
- The Effect of Wenxin Keli on the mRNA Expression Profile of Rabbits with Myocardial Infarction.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These esters appeared to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. As shown by molecular modeling, they are rather bound at the surface of the enzyme and are not submersed in its binding cavities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.