Evidence map›Paper›PMID 26190869›Full record

ArticleTetrahedron letters2015

Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes.

Katsuhiko Mitachi, Shajila Siricilla, Lada Klaic, William M Clemons, Michio Kurosu

Open access · greenAbstract read
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Oxyma-based phosphates for racemization-free peptide segment couplings.Journal of peptide science : an official publication of the European Peptide Society · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Katsuhiko MitachiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38163, USA.
Shajila SiricillaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38163, USA.
Lada KlaicDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Bld. Pasadena, CA 91125, USA.
William M ClemonsDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Bld. Pasadena, CA 91125, USA.
Michio KurosuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, TN 38163, USA.
University of Tennessee Health Science Center · USCalifornia Institute of Technology · US

Funding

NIH Pioneer AwardDP1GM105385 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CLEMONS, WILLIAM M. · 2012 to 2015
$3.3M
Targeting MraY: Synthesis and Validation of MraY InhibitorsR01AI084411 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KUROSU, MICHIO · 2010 to 2013
$1.5M
NIAID NIH HHS R01 AI084411NIGMS NIH HHS DP1 GM105385
6 · The paper itself

Abstract

Peptidoglycan (PG) is unique to bacteria, and thus, the enzymes responsible for its biosynthesis are promising antibacterial drug targets. The membrane-embedded enzymes in PG remain significant challenges in studying their mechanisms due to the fact that preparations of suitable enzymatic substrates require time-consuming biological transformations or chemical synthesis. Lipid I (prenyl diphosphoryl-MurNAc-pentapeptide) is an important PG biosynthesis intermediate to study the central enzymes, translocase I (MraY/MurX) and MurG. Lipid I isolated from nature contains the C

Indexed as

Chemoenzymatic synthesisLipid ILipid IIMurGTranslocase I (MraY/MurX)

Identifiers

PMID26190869
PMCPMC4505380
OpenAlexW2075483634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.