Evidence map›Paper›PMID 26190634›Full record

ArticleNeurobiology of aging2015

Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease.

Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rutt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Present and Future of Ultra-High Field MRI in Neurodegenerative Disorders.Current neurology and neuroscience reports · 2018
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Michael M ZeinehDepartment of Radiology, Lucas Center for Imaging, Stanford University, Stanford, CA, USA. Electronic address: mzeineh@stanford.edu.
Yuanxin ChenImaging Research Laboratories, Robarts Research Institute, Western University, London, Ontario, Canada.
Hagen H KitzlerDepartment of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Robert HammondDepartment of Pathology and Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Hannes VogelDepartment of Pathology, Stanford University, Stanford, CA, USA.
Brian K RuttDepartment of Radiology, Lucas Center for Imaging, Stanford University, Stanford, CA, USA.
Stanford University · USWestern University · CAStanford Medicine · USUniversity Hospital Carl Gustav Carus · DE

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Next Generation 7T MRI Platform Upgrade with Parallel Transmit CapabilitiesS10RR026351 · NCRR · STANFORD UNIVERSITY · PI RUTT, BRIAN KEITH · 2011 to 2011
$600k
NCRR NIH HHS S10 RR026351NIBIB NIH HHS P41 EB015891
6 · The paper itself

Abstract

Although amyloid plaques and neurofibrillary pathology play important roles in Alzheimer disease (AD), our understanding of AD is incomplete, and the contribution of microglia and iron to neurodegeneration is unknown. High-field magnetic resonance imaging (MRI) is exquisitely sensitive to microscopic iron. To explore iron-associated neuroinflammatory AD pathology, we studied AD and control human brain specimens by (1) performing ultra-high resolution ex vivo 7 Tesla MRI, (2) coregistering the MRI with successive histologic staining for iron, microglia, amyloid beta, and tau, and (3) quantifying the relationship between magnetic resonance signal intensity and histological staining. In AD, we identified numerous small MR hypointensities primarily within the subiculum that were best explained by the combination of microscopic iron and activated microglia (p = 0.025), in contradistinction to the relatively lesser contribution of tau or amyloid. Neuropathologically, this suggests that microglial-mediated neurodegeneration may occur in the hippocampal formation in AD and is detectable by ultra-high resolution MRI.

Indexed as

AcetylcholinesteraseAgedAged, 80 and overAlzheimer DiseaseAmyloidAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenFemaleHippocampusHumansImage Processing, Computer-AssistedIronMagnetic Resonance ImagingMaleMicrogliaAcetylcholinesteraseAmyloidAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenIronReceptors, Cell Surfacetau ProteinsAlzheimerAmyloidHippocampusIronMicrogliaMRI

Identifiers

PMID26190634
PMCPMC4839298
OpenAlexW1819889766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.