Evidence map›Paper›PMID 26190350›Full record

ArticleMagnetic resonance in medicine2016

Repeatability and variability of myocardial perfusion imaging techniques in mice: Comparison of arterial spin labeling and first-pass contrast-enhanced MRI.

Nivedita K Naresh, Xiao Chen, Eric Moran, Yikui Tian, Brent A French, Frederick H Epstein

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guidelines for measuring cardiac physiology in mice.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Article
  3. Article
  4. Article
  5. Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  6. Molecular Mechanisms of Adenosine Stress T1 Mapping.Circulation. Cardiovascular imaging · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Myocardial arterial spin labeling.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nivedita K NareshDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Xiao ChenDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Eric MoranDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Yikui TianDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Brent A FrenchDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
Frederick H EpsteinDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.

Funding

MRI of Myocardial Function in Post-Infarct Knockout MiceR01EB001763 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI EPSTEIN, FREDERICK H · 2003 to 2020
$5.4M
94 TESLA MR SCANNER FOR MURINE IMAGING: IMAGINGS10RR019911 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BERR, STUART S · 2005 to 2005
$2.0M
Multi-parameter CMR of post-MI Left Ventricular Remodeling in Gene Modified MiceR01HL115225 · NHLBI · UNIVERSITY OF VIRGINIA · PI FRENCH, BRENT A · 2013 to 2016
$1.5M
NCRR NIH HHS S10 RR019911NHLBI NIH HHS R01 HL115225NIBIB NIH HHS R01 EB001763
6 · The paper itself

Abstract

purposePreclinical imaging of myocardial blood flow (MBF) can elucidate molecular mechanisms underlying cardiovascular disease. We compared the repeatability and variability of two methods, first-pass MRI and arterial spin labeling (ASL), for imaging MBF in mice.

methodsQuantitative perfusion MRI in mice was performed using both methods at rest, with a vasodilator, and one day after myocardial infarction. Image quality (score of 1-5; 5 best), between-session coefficient of variability (CVbs ), intra-user coefficient of variability (CVintra-user ), and inter-user coefficient of variability (CVinter-user ) were assessed. Acquisition time was 1-2 min for first-pass MRI and approximately 40 min for ASL.

resultsImage quality was higher for ASL (3.94 ± 0.09 versus 2.88 ± 0.10; P < 0.05). Infarct zone CVbs was lower with first-pass (17 ± 3% versus 46 ± 9%; P < 0.05). The stress perfusion CVintra-user was lower for ASL (3 ± 1% versus 14 ± 3%; P < 0.05). The stress perfusion CVinter-user was lower for ASL (4 ± 1% versus 17 ± 4%; P < 0.05).

conclusionFor low MBF conditions such as infarct, first-pass MRI is preferred due to better repeatability and variability. At high MBF such as at vasodilation, ASL may be more suitable due to superior image quality and lower user variability. First-pass MRI has a substantial speed advantage. Magn Reson Med 75:2394-2405, 2016. © 2015 Wiley Periodicals, Inc.

Indexed as

AnimalsContrast MediaHeartImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMyocardial Perfusion ImagingReproducibility of ResultsContrast MediaASLcardiac MRIfirst-pass MRImousemyocardial perfusion imaging

Identifiers

PMID26190350
PMCPMC4720592

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.