ArticleDevelopmental cognitive neuroscience2015
Reduced cerebellar brain activity during reward processing in adolescent binge drinkers.
Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Higher alcohol use is associated with subsequent increased risk seeking toward gains: A longitudinal cohort study in young men.Alcohol, clinical & experimental research · 2025Article
- Adolescent alcohol exposure reduces dopamine 1 receptor modulation of prelimbic neurons projecting to the nucleus accumbens and basolateral amygdala.Addiction neuroscience · 2022Article
- Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.Current behavioral neuroscience reports · 2022Article
- Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review.Frontiers in neuroscience · 2022Review
- Brain responses to anticipatory cues and milkshake taste in obesity, and their relationship to bariatric surgery outcome.NeuroImage · 2021Article
- Ventral striatal resting-state functional connectivity in adolescents is associated with earlier onset of binge drinking.Drug and alcohol dependence · 2021Article
- Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data.Drug and alcohol dependence · 2021Article
- Bidirectional links between adolescent brain function and substance use moderated by cognitive control.Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Does Alcohol Initiation in Early-To-Middle Adolescence Predict Changes in Reward Motivation? Evidence of Sex Differences.Alcoholism, clinical and experimental research · 2020Article
- Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking.Addiction biology · 2020Article
- Effect of alcohol use on the adolescent brain and behavior.Pharmacology, biochemistry, and behavior · 2020Review
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Connecting brain responsivity and real-world risk taking: Strengths and limitations of current methodological approaches.Developmental cognitive neuroscience · 2018Review
- Ventral striatal response during decision making involving risk and reward is associated with future binge drinking in adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity to Reward in Binge Drinkers.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Binge drinking and family history of alcoholism are associated with an altered developmental trajectory of impulsive choice across adolescence.Addiction (Abingdon, England) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Due to ongoing development, adolescence may be a period of heightened vulnerability to the neurotoxic effects of alcohol. Binge drinking may alter reward-driven behavior and neurocircuitry, thereby increasing risk for escalating alcohol use. Therefore, we compared reward processing in adolescents with and without a history of recent binge drinking. At their baseline study visit, all participants (age=14.86 ± 0.88) were free of heavy alcohol use and completed a modified version of the Wheel of Fortune (WOF) functional magnetic resonance imaging task. Following this visit, 17 youth reported binge drinking on ≥3 occasions within a 90 day period and were matched to 17 youth who remained alcohol and substance-naïve. All participants repeated the WOF task during a second visit (age=16.83 ± 1.22). No significant effects were found in a region of interest analysis of the ventral striatum, but whole-brain analyses showed significant group differences in reward response at the second study visit in the left cerebellum, controlling for baseline visit brain activity (p/α<0.05), which was negatively correlated with mean number of drinks consumed/drinking day in the last 90 days. These findings suggest that binge drinking during adolescence may alter brain activity during reward processing in a dose-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.