Evidence map›Paper›PMID 26189835›Full record

SynthesisMolecular neurobiology2016

CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population.

Yongning Li, Dongjing Song, Yongshuai Jiang, Jingwei Wang, Rennan Feng, Liangcai Zhang, Guangyu Wang, Zugen Chen, Renzhi Wang, Qinghua Jiang and 1 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Different Associations Between theFrontiers in genetics · 2020
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  17. Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongning LiDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Dongjing SongDepartment of Neurology, The Second Hospital of Harbin, Harbin, China.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Jingwei WangDepartment of Neurology, The Second Hospital of Harbin, Harbin, China.
Rennan FengDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Liangcai ZhangDepartment of Statistics, Rice University, Houston, TX, USA.
Guangyu WangDepartment of Oncology, The First Hospital of Harbin, Harbin, China.
Zugen ChenDepartment of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
Renzhi WangDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. wangrz@126.com.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China. qhjiang@hit.edu.cn.
Guiyou LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. liuguiyou1981@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent genome-wide association studies (GWAS) reported CR1 rs3818361 polymorphism to be an Alzheimer's disease (AD) susceptibility variant in European ancestry. Three independent studies investigated this association in Chinese population. However, these studies reported weak or no significant association. Here, we reinvestigated the association using all the samples from three independent studies in Chinese population (N = 4047, 1244 AD cases and 2803 controls). We also selected three independent studies in European ancestry population (N = 11787, 3939 AD cases and 7848 controls) to evaluate the effect of rs3818361 polymorphism on AD risk in different ethnic backgrounds. In Chinese population, we did not identified significant heterogeneity using additive, recessive, and dominant genetic models. Meta-analysis showed significant association between rs3818361 and AD with P = 6.00E-03 and P = 5.00E-03. We further identified no heterogeneity of rs3818361 polymorphism between Chinese and European populations. We found that rs3818361 polymorphism contributed to AD with similar genetic risk in Chinese and European populations. In summary, this is the first study to show significant association between rs3818361 polymorphism and AD in Chinese population by a meta-analysis method. Our findings indicate that the effect of CR1 rs3818361 polymorphism on AD risk in Chinese cohorts is consistent with the increased risk observed in European AD cohorts.

Indexed as

Genetic Predisposition to DiseaseAlzheimer DiseaseAsian PeopleCase-Control StudiesGenes, RecessiveGenetic HeterogeneityHumansModels, GeneticPolymorphism, Single NucleotidePublication BiasReceptors, Complement 3bCR1 protein, humanReceptors, Complement 3bAlzheimer’s diseaseGenome-wide association studiesPolymorphism

Identifiers

PMID26189835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.