ArticleNature communications2015
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Abstract readTwin Study
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Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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26citing papers in PubMed, 2 pooled it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- A genome-wide association study reveals a substantial genetic basis underlying the Ebbinghaus illusion.Journal of human genetics · 2021Pooled it
- Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults.Frontiers in aging neuroscience · 2026Article
- Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Causal effects of cingulate morphology on executive functions in healthy young adults.Human brain mapping · 2022Article
- Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns.Human brain mapping · 2020Article
- Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.NeuroImage. Clinical · 2020Article
- Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Baby brain atlases.NeuroImage · 2019Review
- Article
- Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes.Translational psychiatry · 2018Article
- Asynchronous evolution of interdependent nest characters across the avian phylogeny.Nature communications · 2018Article
- Beyond heritability: improving discoverability in imaging genetics.Human molecular genetics · 2018Review
- Joint Analysis of Cortical Area and Thickness as a Replacement for the Analysis of the Volume of the Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Brain cortical characteristics of lifetime cognitive ageing.Brain structure & function · 2018Article
- Neuroimaging genomics in psychiatry-a translational approach.Genome medicine · 2017Review
- Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure.Scientific reports · 2017Article
- Toward a conceptual framework for early brain and behavior development in autism.Molecular psychiatry · 2017Review
- Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Review
Corrections and comments
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Authors and funding
26 authors.
Chi-Hua ChenMultimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA.
Qian Peng1] Department of Human Biology, J. Craig Venter Institute, San Diego, California 92037, USA. [2] Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, California 92037, USA.
Andrew J Schork1] Multimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA. [2] Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA.
Min-Tzu LoMultimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA.
Chun-Chieh Fan1] Multimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA. [2] Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA.
Yunpeng Wang1] Multimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA. [2] Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA. [3] Norwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway.
Rahul S DesikanMultimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA.
Francesco BettellaNorwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway.
Donald J HaglerMultimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA.
Pediatric Imaging, Neurocognition and Genetics Study
Alzheimer’s Disease Neuroimaging Initiative
Lars T Westlye1] NORMENT, KG Jebsen Centre for Psychosis Research, Department of Psychology, University of Oslo, 0424 Oslo, Norway. [2] NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, 0317 Oslo, Norway.
William S Kremen1] Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA. [2] VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, California 92037, USA.
Terry L Jernigan1] Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA. [2] Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA.
Stephanie Le Hellard1] Dr E. Martens Research Group of Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway. [2] NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Norway.
Vidar M Steen1] Dr E. Martens Research Group of Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway. [2] NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Norway.
Thomas Espeseth1] NORMENT, KG Jebsen Centre for Psychosis Research, Department of Psychology, University of Oslo, 0424 Oslo, Norway. [2] NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, 0317 Oslo, Norway.
Matt HuentelmanTranslational Genomics Research Institute, Phoenix, Arizona 85004, USA.
Asta K Håberg1] Department of Neuroscience, Norwegian University of Science and Technology (NTNU), 7489 Trondheim, Norway. [2] Department of Medical Imaging, St. Olav's University Hospital, 7006 Trondheim, Norway.
Ingrid Agartz1] Norwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway. [2] Department of Psychiatric Research, Diakonhjemmet Hospital, 0319 Oslo, Norway.
Srdjan Djurovic1] NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Norway. [2] Department of Medical Genetics, Oslo University Hospital, 0424 Oslo, Norway.
Ole A AndreassenNorwegian Center for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway.
Nicholas SchorkDepartment of Human Biology, J. Craig Venter Institute, San Diego, California 92037, USA.
Anders M Dale1] Multimodal Imaging Laboratory, Department of Radiology, University of California San Diego, La Jolla, California 92037, USA. [2] Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA. [3] Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA.
Pediatric Imaging Neurocognition and Genetics Study
Alzheimer's Disease Neuroimaging Initiative
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MSystems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI Thomas Girke, NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MThe VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8MThe VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7MCreating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1MNeural Basis of Emergent Math Difficulties in Healthy Preterm ChildrenR01HD075865 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKSHOOMOFF, NATACHA · 2013 to 2017
$3.0MIdentifying the Polygenic Basis of the Human Brain and Psychiatric DisordersR01MH100351 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2013 to 2017
$2.1MCIHRNIA NIH HHS AG18384NIA NIH HHS AG18386NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01AG22381NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG023122NIDA NIH HHS RC2 DA029475NIDA NIH HHS RC2DA029475NIMH NIH HHS R01 MH100351NIMH NIH HHS R01MH100351
Abstract
Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface area is explained by additive effects of SNPs dispersed throughout the genome, with a larger heritable effect for visual and auditory sensory and insular cortices (h(2)∼0.45). Genome-wide SNPs collectively account for, on average, about half of twin heritability across cortical regions (N=466 twins). We find enriched genetic effects in or near genes. We also observe that SNPs in evolutionarily more conserved regions contributed significantly to the heritability of cortical surface area, particularly, for medial and temporal cortical regions. SNPs in less conserved regions contributed more to occipital and dorsolateral prefrontal cortices.
Indexed as
GenomicsAdolescentAdultAgedAged, 80 and overBase SequenceCerebral CortexChildChild, PreschoolConserved SequenceFemaleGenome, HumanGenotypeHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging
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