ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Genetic Moderation of Stress Effects on Corticolimbic Circuitry.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2024Review
- The Effects of Variation in the GABANeuropsychiatric disease and treatment · 2024Article
- Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala.Molecular psychiatry · 2023Article
- Brain Reactions to Opening and Closing the Eyes: Salivary Cortisol and Functional Connectivity.Brain topography · 2022Article
- Title: "Labels Matter: Is it stress or is it Trauma?"Translational psychiatry · 2021Review
- Review
- The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients.Pharmacological reports : PR · 2020Article
- The MAOA Gene Influences the Neural Response to Psychosocial Stress in the Human Brain.Frontiers in behavioral neuroscience · 2020Article
- Article
- At-risk individuals display altered brain activity following stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Neuroimaging genomics in psychiatry-a translational approach.Genome medicine · 2017Review
- Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.Biological psychiatry · 2017Review
- Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.Psychoneuroendocrinology · 2017Article
- Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Mediating Role of the Reward Network in the Relationship between the Dopamine Multilocus Genetic Profile and Depression.Frontiers in molecular neuroscience · 2017Article
- Dispositional negativity: An integrative psychological and neurobiological perspective.Psychological bulletin · 2016Review
- Neuroimaging genetic approaches to Posttraumatic Stress Disorder.Experimental neurology · 2016Review
- Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Genetic and Environmental Factors Associated with Cannabis Involvement.Current addiction reports · 2016Article
- Intensified vmPFC surveillance over PTSS under perturbed microRNA-608/AChE interaction.Translational psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Stress exposure is associated with individual differences in corticolimbic structure and function that often mirror patterns observed in psychopathology. Gene x environment interaction research suggests that genetic variation moderates the impact of stress on risk for psychopathology. On the basis of these findings, imaging genetics, which attempts to link variability in DNA sequence and structure to neural phenotypes, has begun to incorporate measures of the environment. This research paradigm, known as imaging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the neural mechanisms through which genetic variation and stress increase psychopathology risk. Although awaiting replication, evidence suggests that genetic variation within the canonical neuroendocrine stress hormone system, the hypothalamic-pituitary-adrenal axis, contributes to variability in stress-related corticolimbic structure and function, which, in turn, confers risk for psychopathology. For iGxE research to reach its full potential it will have to address many challenges, of which we discuss: (i) small effects, (ii) measuring the environment and neural phenotypes, (iii) the absence of detailed mechanisms, and (iv) incorporating development. By actively addressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying genetic and environmental associations with psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.