Evidence map›Paper›PMID 26189130›Full record

ArticleEuropean journal of nutrition2016

Diet-related inflammation and oesophageal cancer by histological type: a nationwide case-control study in Sweden.

Yunxia Lu, Nitin Shivappa, Yulan Lin, Jesper Lagergren, James R Hébert

Open access · greenAbstract read
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In one paragraph

Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 6 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 4 countries.

Yunxia LuDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden. yunxia.lu@ki.se.
Nitin ShivappaCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
Yulan LinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden.
Jesper LagergrenDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden.
James R HébertCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
Karolinska Institutet · SEUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer.

methodsA nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or gastroesophageal junction and a randomly selected half of patients with oesophageal squamous cell carcinoma were eligible as cases. Using the Swedish Registry of the Total Population, the control group was randomly selected from the entire Swedish population and frequency-matched on age (within 10 years) and sex. The literature-derived dietary inflammatory index (DII) was developed to describe the inflammatory potential of diet. DII scores were computed based on a food frequency questionnaire. Higher DII scores indicate more pro-inflammatory diets. Odds ratios and 95 % confidence intervals (CI) were computed to assess risk associated between DII scores and oesophageal cancer using logistic regression adjusted by potential confounders.

resultsIn total, 189 oesophageal adenocarcinomas, 262 gastroesophageal junctional adenocarcinomas, 167 oesophageal squamous cell carcinomas, and 820 control subjects were recruited into the study. Significant associations with DII were observed for oesophageal squamous cell carcinoma (ORQuartile4vs1 4.35, 95 % CI 2.24, 8.43), oesophageal adenocarcinoma (ORQuartile4vs1 3.59, 95 % CI 1.87, 6.89), and gastroesophageal junctional adenocarcinoma (ORQuartile4vs1 2.04, 95 % CI 1.24, 3.36). Significant trends across quartiles of DII were observed for all subtypes of oesophageal cancer.

conclusionsDiet-related inflammation appears to be associated with an increased risk of oesophageal cancer, regardless of histological type.

Indexed as

DietAdenocarcinomaAgedBody Mass IndexCarcinoma, Squamous CellCase-Control StudiesDiet SurveysEducational StatusEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaExerciseFemaleHelicobacter InfectionsHumansInflammationLogistic ModelsDietInflammationNeoplasmOesophagus

Identifiers

PMID26189130
OpenAlexW1768297412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.